Softgel drug formulations

Perry, C.M. Noble, S. Saquinavir softgel capsule formulation. A review of its use in patients with HIV infection. Drugs 1998, 55 (3), 461-486. 

Patel M. S., F. S. Morton, H. Seager, and D. Howard. 1992. Factors affecting the chemical stability of carboxylic acid drugs in enhanced solubility system (ESS) softgel formulations based on polyethylene glycol (PEG).Drug Development and Industrial Pharmacy, 18 1-19. 

The pharmacokinetic performance of drugs can be enhanced by Softgel dosage form, the exact formulation... 

Over the 1990 and 2000 periods, 95%i of patents granted for pharmaceutical Softgel products relate to drugs or fill formulations and not to specific claims or improvements regarding shell formulations or manufacturing processes. On the surface, this would appear to indicate a mature technology, but as patents are public domain, and process patents are difficult to enforce, it is more likely that industry leaders are reluctant to pursue patents, except in unusual circumstances. In this process critical industry, it is more reasonable to expect that companies prefer to maintain technological advances as internal in-house matters for competitive reasons. 

R.P. Scherersol system Liquid formulations for softgels, which incorporates the drug in a microemulsion preconcentrate or microemulsion form. Oral delivery of proteins and peptides enhanced oral bioavailability with reduced inter- and intraindividual variability in pharmacokinetics of certain drugs. Sandimmune Neoral (cyclosporine). 

Hutchinson, K. Formulation of softgels for improved oral delivery of hydrophobic drugs. In Excipients and Delivery Systems for Pharmaceutical Formulations, Royal Society of Chemistry Cambridge, 1995 133-147. 

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