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Soft method

Although there has been some controversy concerning the processes involved in field ionization mass spectrometry, the general principles appear to be understood. Firstly, the ionization process itself produces little excess of vibrational and rotational energy in the ions, and, consequently, fragmentation is limited or nonexistent. This ionization process is one of the mild or soft methods available for producing excellent molecular mass information. The initially formed ions are either simple radical cations or radical anions (M ). [Pg.25]

FI and FD are mild or soft methods of ionization that produce abundant molecular or quasi-molecular positive or negative ions from a very wide range of substances. In the FD mode, it is particularly useful for high-molecular-mass and/or thermally labile substances such as polymers, peptides, and carbohydrates. [Pg.27]

When colloids are involved in catalysis, the separation of catalyst by means of solvent evaporation becomes inappropriate because the agglomeration of particles is then favoured [3]. Soft methods like filtration or centrifugation turn out to be more convenient. [Pg.430]

Haick H, Cahen D (2008) Contacting organic molecules by soft methods towards molecule-based electronic devices. Acc Chem Res 41 359-366... [Pg.112]

Such a scheme is sometimes called a soft Newton-Raphson formulation because the partial derivatives in the Jacobian matrix are incomplete. We could, in principle, use a hard formulation in which the Jacobian accounts for the devia-tives dy/dm,i and daw/dm,i. The hard formulation sometimes converges in fewer iterations, but in tests, the advantage was more than offset by the extra effort in computing the Jacobian. The soft method also allows us to keep the method for calculating activity coefficients (see Chapter 8) separate from the Newton-Raphson formulation, which simplifies programming. [Pg.66]

Field desorption FD Desorption/ionization by strong electric field Nonvolatile molecular ions First soft method Large molecules... [Pg.17]

Electrospray ionization ESI Spray Nonvolatile molecular ions Soft method, LC-MS Large molecules... [Pg.17]

Interaction equilibria, e.g., between drugs, excipients, vehicle systems, and biological structures, reflect the sum of interactions, which are nonspecific (hydrophobic) and specific (electrostatic dipole-dipole and dipole-induced dipole and hydrogen bonding). The soft method of ACE does not disturb the sensitive equilibria via any chemical modification. [Pg.11]

Electrospray mass spectrometry (ESMS) — The electrospray component of ESMS [i] provides a very soft method of transferring ions from solution to the gas phase with minimal risk of decomposition and fragmentation of ions prior to their determination by mass spectrometry. Ideally suited for the determination of charged solution species which are frequently generated in electrochemical experiments [ii]. [Pg.244]

Soft ionization methods produce few fragments under relatively mild conditions. The ionization method that has received the most attention in terms of its applicability to protein and DNA analysis is the electrospray ionization (ES) technique. This is a soft method that is capable of generating molecular ions from biological macromolecules present in solution. Table 12.3 gives examples of the charge and m/z ranges that have been observed with some biopolymer species in electrospray ionization mass spectrometers. [Pg.235]

The ion source used for the generation of biomolecular parent ions is critical, and only recently have the so-called soft ionization methods been developed.2 Electron-impact ionization sources fall into the category of hard sources, whereby the sample must be in the vapor phase initially, and the ionization process produces a very large number of fragments. Soft methods were introduced to overcome the problems associated with the thermal instability and involatility of macromolecular analytes. Soft ionization produces few fragments under relatively mild conditions. In Table 15.1 a comparison is shown between the three main soft ionization methods some of these values are strongly dependent on individual mass spectrometer configurations and the desired resolution. [Pg.297]

The measurement of MIKE spectra to elucidate ion structures and to study fragmentation mechanisms remains the method of choice, providing they lead to numerous fragmentations, which is not always the case when soft methods, such as Cl, FD, etc., are utilized. It is necessary to use an ionization which transmits a higher energy to the molecular ions. A larger number of fragments can be observed for the ions which decompose in the second FFR. [Pg.172]

The advantage of these soft methods of ionization is to obtain pseudomolecular and multicharged ions (z can be greater than 30), formed prior to entry into the spectrometer. With the exception of APCI they are able to extend the range... [Pg.399]

Chemical Relatively GC or liquid-solid To 1000 Soft method. Molecular... [Pg.595]

Electrospray Peptides, Liquid chromatography To 200,000 Soft method. Ions often... [Pg.595]

Matrix-assisted Peptides, Sample mixed in To 500,000 Soft method, very... [Pg.595]

The disadvantage of this approach is that the resulting oxides are not highly crystallised because heat treatment cannot be conducted at a temperature above about 400 °C, where structural collapse occurs. This soft method has not been applied for ordered mesoporous crystalline late transition metal (such as Cu, Co, Ni and Fe) oxides. As a rare case, preparation of mesoporous nickel or iron oxide was reported. However, nickel oxide has an amorphous wall and iron oxide (crystalline y-Fe203) has disordered wormhole mesopores. ... [Pg.155]

Pomerantsev, A. L. Rodionova, O. Y. Flard and soft methods for prediction of antioxidants activity based on the DSC measurements. Chemometrics and Intelligent Laboratory Systems, 2005, 79(1-2), 73-83. [Pg.22]

Electrospray ionization (ESI) In MS, a soft method to ionize directly from ions in a solution. [Pg.3771]

A Soft Method for Developing Nanostructured Organic Biomaterials... [Pg.173]

In matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry, a UV laser is used to generate atoms, M, of the sample [M + H] or [M + Na] ions are typically detected. It is a soft method and there is little fragmentation. [Pg.96]

Reverse microemulsion, a rather soft method, has been used to prepare hollow titania microspheres [51] TiCLi was dissolved in HCl-acidified water and added to a solution of TX-lOO in cycloheptane after addition of ammonia and stirring... [Pg.15]

While FAB and LSIMS are useful and versatile soft methods, they have widely been replaced by matrix-assisted laser desorption/ionization (MALDI, Chap. 11), electrospray ionization (ESI, Chap. 12), and related API techniques. Therefore, we will restrict ourselves to a brief introduction of FAB and LSIMS. [Pg.480]

In solution and in gas phase, the characterization of self-assembled cages/ capsules requires analytical methods operating in timescales that are in accordance with their hfetimes (milliseconds to hours). NMR spectroscopy and mass spectrometry using soft methods (ESI, MALDI) for vaporization and ionization are appropriate. In some cases, the containers structures and their complexes have also been characterized in the solid state by X-ray diffiraction. Generally, the purification of supramolecular containers and their encapsulation complexes using chromatography is not feasible owing to dynamic features of the reversible self-assembly process that led to their formation. [Pg.844]


See other pages where Soft method is mentioned: [Pg.423]    [Pg.373]    [Pg.331]    [Pg.332]    [Pg.136]    [Pg.274]    [Pg.15]    [Pg.420]    [Pg.948]    [Pg.96]    [Pg.190]    [Pg.66]    [Pg.83]   
See also in sourсe #XX -- [ Pg.330 ]




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