Sodium starch glycolate cross linking

Disintegrants and superdisintegrants Starch, sodium starch glycollate, cross-linked polyvinyl pyrrolidone... 

Fig. 16 Disintegrants. Primojel (A), Explotab, sodium starch glycolates (B), cross-linked carboxymethyl cellulose (C), and calcium carboxymethyl cellulose (D).

Sodium starch glycolate is the sodium salt of a poly-ot-glucopyranose in which some of the hydroxyl groups are in the form of the carboxymethyl ether (Fig. 6). Starch is carboxymethylated by reacting it with sodium chloroacetate in an alkaline medium followed by neutralization with acid. Cross-linking is achieved by physical or chemical methods. The sodium starch... 

Sodium starch glycolate is a super disintegrant made from cross-linking sodium carboxymethylstarch. Cross-linking involves a chemical reaction with phosphorus oxytrichloride or sodium trimetaphosphate, or a physical... 

Sodium starch glycolate is a substituted derivative of potato starch. Typically, commercial products are also cross-linked. 

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