Sodium oxybate Foods

Bolla KI, McCann UD, Ricaurte GA Memory impairment in abstinent MDMA ( ecstasy ) users. Neurology 51 1532—1537, 1998 Borgen L, Lane E, Lai A Xyrem (sodium oxybate) a study of dose proportionality in healthy human subjects. J Clin Pharmacol 40 1053, 2000 Borgen LA, Okerholm R, Morrison D, et al The influence of gender and food on the pharmacokinetics of sodium oxybate oral solution in healthy subjects. J Clin Pharmacol 43 59-65, 2003... 

Borgen, L.A., Lai, A. and Okerholm, R.A. (2001). Xyrem (sodium oxybate) the effects of gender and food on plasma kinetics. Orphan Medical, Inc., Minnetonka, MN, personal communication. 

In a study in 34 healthy subjects 4.5 g of sodium oxybate solution was given after a high-fat meal. It was found that food delayed the time to maximum level from 0.75 to 2 hours, reduced the maximum level by 58% and reduced the AUC by 35%, when compared with the fasted state.- The first dose of sodium oxybate should be taken at least 2 to 3 hours after the evening meal, and patients should always try to keep the same timing of dosing in relation to meals. - ... 

Patients taking sodium oxybate shouid not drink aicohoiic beverages with sodium oxybate. Additive CNS depressant effects are predicted with other CNS depressant drugs, and concurrent use of sedative hypnotics shouid be avoided. No pharmacokinetic interaction occurs with omeprazoie, protriptyiine, zoipidem or mo-daflnii, but a pharmacodynamic interaction cannot be ruled out. Food markedly delays and modestly reduces the absorption of sodium oxybate. 

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See also in sourсe #XX -- [ ]

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