Sodium dehydrocholate

Sodium Dchydrocholate (City Chem.) wfm Sodium Dehydrocholate (Endo) wfm... 

This paper reports the systematic study of the apparent anhydrous micellar weights of the three principal bile salts found in man and their glycine and taurine conjugates in respect to bile salt concentration, counterion concentration, temperature, pH, and urea concentration. On the basis of these studies, model structures of bile salt micelles are proposed. Sodium dehydrocholate, a triketo bile salt, was also studied but was not found to form micelles. 

Debridat (Sigma-Tau)- Cholan-DH (Pennwalt) Sodium Dehydrocholate... 

Administration of high doses of sodium dehydrocholate (B49, C3, M16, M27), or of sodium taurocholate (03, W15) decreases the clearance of BSP from plasma. Both uptake and excretion rates appear to be affected. The plasma retention of indocyanine green (H28), uranin (H3), and bilirubin (C3) were also elevated on administration of sodium dehydrocholate. This inhibitory effect has been ascribed to competition for the uptake carrier (H28) and the carrier sites on the excretory membrane... 

Bile salts have been used for centuries as digestive aids and cathartics. Their use for these purposes has become more limited recently, and this is probably appropriate until better preparations become available and indications for their administration become more clearly defined. Most commercial bile salt preparations are desiccated or crude extracts of cattle bile containing mainly unconjugated bile salts with small amounts of pigment and lipids. They are generally supplied as 0.2- or 0.3-g tablets. The customary dose is 0.4-0.6 g three times daily with meals. This is probably an inadequate dose, as will be explained later. Dehydrocholic acid, 3,7,12-triketo-5j -cholanoic acid, is oxidized cholic acid and is supplied in pure form but does not form micelles and hence probably does not assist fat absorption significantly and would be of little value for replacement therapy. Sodium dehydrocholate is supplied as a 20 % solution in ampules and is widely used to measure blood circulation times. It does not appear to be conjugated by the liver (86). 

NaC = sodium cholate NaDHC = sodium dehydrocholate THAI = tetraethylammonium iodide Xy = xyiene Tl = toluene Bz = benzene Np = naphthalene Hp = heptane. 

The methyl ester of the acid can very conveniently be prepared by esterifying in ten parts of methyl alcohol with hydrogen chloride. After boiling for quite a short time, the cold solution, saturated with hydrogen chloride, is poured into a large volume of dilute sodium carbonate solution, and the ester, which is precipitated in solid form, is dried and recrystallised from a little dilute methyl alcohol. Other compounds which may suitably be prepared are dehydrocholic add, cholatrienic add, and cholanic add. 

Respective ketocholanic acids, which are absent from bile, can be obtained from C, DC, and LC by oxidation of secondary alcohohc groups (dehydrogenation). Dehydrocholic acid, used both in a free and conjugated form (of sodium salt), is about 10 times less toxic than C. Dehydrocholic acid activates production of bile, speeds up its flow, and facilitates resorption of fat because it intensifies the activity of pancreatic hpase. Bile acids are weU absorbed from the alimentary tract next, they enter the blood stream and then activate hvCT cells to produce bile. However, bile acids are strongly toxic compounds, and their overdose leads to degeneration of... 

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