Sodium alpha ketoglutarate

Hume AS, Mozigo JR, McIntyre B, et al. 1995. Antidotal efficacy of alpha-ketoglutaric acid and sodium thiosulfate in cyanide poisoning. Clinical Toxicol 33(6) 721-724. [Pg.254]

Tulsawani, R.K., Debnath, M., Pant, S.C., Om Kumar, Prakash, A.O., Vijayaraghavan, R., Bhattacharya, R. (2005). Effect of sub-acute oral cyanide administration in rats protective efficacy of alpha-ketoglutarate and sodium thiosulfate. Chemico-Biol. Int. 156 1-12. [Pg.269]

A further consequence of thiamine depletion during parenteral nutrition can be severe lactic acidosis (44). Six cases have been described from Japan with associated hypotension, Kussmaul s respiration, and clouding of consciousness, as well as abdominal pain not directly related to the underlying disease. During parenteral nutrition administration there was blockade of oxidative decarboxylation of alpha-keto acids such as pyruvate and alpha-ketoglutarate, resulting in pjruvate accumulation and massive lactate production. None of the patients responded to sodium bicarbonate or other conventional emergency treatments for shock and lactic acidosis. Thiamine replenishment with intravenous doses of 100 mg every 12 hours resolved the lactic acidosis and improved the clinical condition of three patients. [Pg.2704]

OAT1 PAH transporter, sodium and alpha-ketoglutarate dependent. Classical organic anion transporter [39]... [Pg.32]

AT3 PAH transporter independently from alpha-ketoglutarate and sodium [80a]... [Pg.32]

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