Smooth muscles garlic

Garlic clearly has antithrombotic properties. Ajoene (an allicin metabolite) and methyl allyl trisulfide inhibit platelet aggregation. Garlic may promote vasodilation by relaxing smooth muscle, and it may reduce low-density lipoprotein (LDL) oxidation. 

Small doses of garlic are purported to increase the tone of smooth muscle in the gastrointestinal tract, while large doses decrease such actions (Tyler, 1993). An ethanol—chloroform extract of fresh bulb antagonized acetylcholine and prostaglandin E induced rat fundus smooth muscle contraction at a concentration of 0.002 mg/mL however, an ethanol extract of fresh garlic bulb caused rat fundus smooth muscle stimulation at a concentration of 0.016 mg/mL (Ross, 1998). 

Garlic oil acts as a gastrointestinal smooth muscle relaxant, suggested for further research in patients with hypermotile intestinal disorders. ... 

Aqueous extracts of raw garlic also inhibited cyclooxygenase activity in rabbit platelets, again contributing to an antithrombotic effect. In addition, AGE and S-allyl cysteine and S-allyl mercapto-cysteine have antiplatelet adhesion effects. Platelet adhesion to the endothelial surface is involved in atherosclerosis initiation. Furthermore, S-allyl mercaptocysteine inhibits the proliferation of rat aortal smooth muscle cells, another important... 

Aqel MB, Gharaibah MN, Salhab AS (1991) Direct relaxant effects of garlic juice on smooth and cardiac muscles. J Ethnopharmacol 33(1-2) 13-19... 

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