Smart polymer nanocarriers for drug delivery

TALELLI.A. DURO-CASTANO,G. RODRIGUEZ-ESCALONA and M.J.VICENT,Centro de Investigacion 

Key words stimuli responsive, conjugate, micelle, nanoparticle. 

Nanosized drug delivery systems (nanoDDS) have been developed and evaluated. They are considered to be among the most promising approaches to enhancing drug specificity, thereby reducing systemic toxicity (Peer et al, 2007). For the treatment of cancer or other inflammation-related diseases, nanocarriers in general utilize the enhanced permeation and retention 

1 Schematic representation of the different types of polymer therapeutics. Source Reproduced from Canal eta ., 2011 with permission.) 

1 The EPR effect occurs in inflamed areas possessing leaky vasculature this allows preferential extravasation of large molecules (10-200 nm) in the inflamed tissue, and their prolonged retention there owing to the impaired lymphatic drainage (Maeda, 2012). 

---

The problems of bio-functional polymers were diseussed on the 4 session. This session included 6 lectures. The speakers gave information about biofunctional dendritic architectures, biocompatible and bioactive polymers containing saccharide fimctionality, design and mechanisms of antimicrobial polymers, control of protein adsorption on functionalized electrospun fibers, microcapsules and nanoparticles for controlled delivery and repair, smart nanocarriers for bioseparation and responsive drug delivery systems. 

---