Combinatorial parallel synthesis

The bottleneck of conventional parallel/combinatorial synthesis is typically optimization of reaction conditions to afford the desired products in suitable yields and purities. Since many reaction sequences require at least one or more heating steps for extended time periods, these optimizations are often difficult and time-consum-... 

The cation pool method serves as a powerful tool for parallel combinatorial synthesis.25 Required for successful combinatorial synthesis are reactions of high generality to couple any desired combination of molecules we want. The cation pool method seems to be suitable for this purpose, because organic cations generated by this method are usually so highly reactive as to couple with a wide range of nucleophiles. 

Figure 4. Parallel combinatorial synthesis based on the cation pool" method.

The advantages of functional polymers are best realized when used in two situations— multistep sequential reactions and automated parallel combinatorial synthesis to produce libraries of compounds. In both situations there is a large savings in the time and expense of carrying out the many chemical reactions and their corresponding handling and purification steps. 

Adler, F., Turk, G., Frank, R., et al. (2000) A new array format for the automated parallel combinatorial synthesis by the SPOT-technique. In Innovation and Perspectives in Solid Phase Synthesis (Epton, R., ed.), Mayflower Worldwide, Kings-winford, UK, pp. 221-222. 

Figure 4.1 Parallel combinatorial synthesis based on the cation-pool method. (a) Schematic diagram (b) example based on the reaction of N-acyliminium ion pools with carbon nucleophiles...

The cation-pool method serves as a powerful tool for parallel combinatorial synthesis because of high reactivity of cation pools [6]. A typical example is shown in Fig. 2. A solution of a cation Al" ( cation pool ), which is generated by... 

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