Small interfering RNAs screening

Bartz SR, Zhang Z, Burchard J et al (2006) Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions. Mol CeU Biol 26 9377-9386... [Pg.95]

Collins CS, Hong J, Sapinoso L et al (2006) A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase. Proc Natl Acad Sci USA 103 3775-3780... [Pg.247]

McManus, M.T. et al. 2002. Gene silencing in mammals by small interfering RNAs Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance. Nat. Rev. Genet. 3, 737-747. [Pg.261]

Zheng, L., J. Liu, S. Batalov, D. Zhou, A. Orth, S. Ding, and P. Schultz. 2004. An approach to genomewide screens of expressed small interfering RNAs in mammalian cells. Proc Natl Acad Sci USA 101 135-40. [Pg.260]

HT-RNAi screens of mammalian cells primarily use either short interfering RNA (siRNA) or small-hairpin RNA (shRNA) libraries. Although there are similarities between the two platforms, screening using siRNA libraries has the advantages of having minimal... [Pg.89]

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