Small drug discovery

Drug Discovery via Small-Molecule Peptoid Libraries I 7... 

Jang GR, Harris RZ, Lau DT. Pharmacokinetics and its role in small molecule drug discovery research. Med Res Rev 2001 21 382-96. 

Molecules of the simpUcity of ethane or the complexity of proteins and DNA adopt different conformations. In the case of ethane this gives rise to the notion of a staggered and eclipsed bond, whereas proteins form an array of complex structural elements and DNA - the famous double hehx. The understanding of the conformational properties of small molecules is an important factor in computational approaches contributing to drug discovery. 

Recent developments in drug discovery and drug development spurred the need for novel analytical techniques and methods. In the last decade, the biopharmaceutical industry set the pace for this demand. The nature of the industry required that novel techniques should be simple, easily applicable, and of high resolution and sensitivity. It was also required that the techniques give information about the composition, structure, purity, and stability of drug candidates. Biopharmaceuticals represent a wide variety of chemically different compounds, including small organic molecules, nucleic acids and their derivatives, and peptides and proteins. 

Src Homology-2 Domains and Structure-Based, Small-Molecule Library Approaches to Drug Discovery... 

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