Discovery Small Molecule Drugs

Jang GR, Harris RZ, Lau DT. Pharmacokinetics and its role in small molecule drug discovery research. Med Res Rev 2001 21 382-96. 

Annis, D. A., Nickbarg, E., Yang, X., Ziebell, M. R., Whitehurst, . E. (2007) Affinity selection-mass spectrometry screening techniques for small molecule drug discovery. Curr Opin Chem Biol 11, 518-526. 

Alton, G. R., Lunney, E. A. (2009) Targeting the unactivated conformations of protein kinases for small molecule drug discovery. Expert Opin Drug Discov 3, 595-605. 

Balan Chenera (24), Amgen Inc., Department of Small Molecule Drug Discovery, One Amgen Center Drive, Thousand Oaks, California, 91320... 

Fry DC. Protein-protein interactions as targets for small molecule drug discovery. Biopolymers. 2006 84 535-552. 

Hosfield, D., Palan, J., Hilgers, M., Scheibe, D., McRee, D. E., and Stevens, R. C. 2003. A fully integrated protein crystallization platform for small-molecule drug discovery. J. Struct. Biol. 142 207-217. 

Strege, M.A. Sevenson, S. Lawrence, S.M. Mixed-Mode Anion-Cation Exchanged lydrophilic Interaction Liquid Chromatography-Electrospray Mass Spectrometry as an Alternative to Reversed Phase for Small Molecule Drug Discovery, Anal. Chem. 72,4629-4633 (2000). 

Zhao, Y. Chow, D.T. Wilson, J. Woo, G. Semin, D.J. Investigation of a High Throughput Parallel LC-UV-TOF-MS for Small Molecule Drug Discovery, in Proceedings of the HPLC2000 Symposium, Seattle, WA, June 24-30,... 

I thank the authors for their contributions to this volume, and hope that in total this book presents a suitably clear picture of where the field of PPI-directed small-molecule drug discovery has been, what lessons we can take from the past, and, armed with this experience, where the field might be headed. 

---