SMA micelles

In our SMA micelles of pirarubicin or doxorubicin constant release of the anthracycline from micelles was observed, the rate was much slower than the endocytotic process, which showed a release rate of 4-5%/day. In these cases, once the micelles are taken up into the tumor cells, active principle of free drugs will be continuously released. However, pirarubicin, which exhibits higher... 

H. Nakamura, J. Fang, B. Gahininath, K. Tsukigawa, and H. Maeda, Intracellular uptake and behavior of two types zinc protoporphyrin (ZnPP) micelles, SMA-ZnPP and PEG-ZnPP as anticancer agents unique intracellular disintegration of SMA micelles, J. Contr. Rel, 155,367-375,2011. 

AA BAA CMC CPB CTAB DM SO IPC MVPQ PAA PDADMAB PEG PIPAA SDS SMA TEMED acrylamide methylene bisacrylamide critical micelle concentration cetylpyridinium bromide cetyltrimethylammonium bromide dimethylsulfoxide interpolymer complex methylvinylpiridine units quaternized by dimethyl sulfate poly(acrylamide) poly(diallyldimethylammonium bromide) polyethylene glycol) poly(isopropylacrylamide) sodium dodecyl sulfate sodium methacrylate tetramethylethylenediamine... 

Figure 29 shows the dependence of the equilibrium concentration of the cetylpyridinium cations in the anionic gel of SMA-MAA, Cg, on the contents of CPB in the surrounding solution. At low Cs, the Cg values are higher by a factor of 104 than the value of CPB concentration in the solution and they are much higher than the critical micelle concentration (CMC) of CPB in water (3 x 10 4mol/l). One can assume that CPB cations in the gel should form micelle-like aggregates. 

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