Microemulsion-Based SLN Preparations

SLN preparation techniques that are based on the dilution of microemulsions have been developed by Gasco [16]. It should be mentioned that there are different definitions and opinions about the structure and dynamics of microemulsion in the scientific community. An extended review has recently been published by Moulik and Paul [33], 

In addition to the composition, the temperature gradient and the pH value are key parameters for the quality of the final lipid nanosuspension. High-temperature gradients facilitate rapid lipid crystallization and prevent aggregation [36,37], Because of the dilution step, achievable lipid contents are considerably lower compared with the HPH-based formulations. 

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