Sisomicin Netilmicin

The primary application of RIA for antibiotics has been in the medical area, and primarily for antibiotics not used in agriculture. Assays have been developed for gentamicin tobramycin, sisomicin, netilmicin and for hygromycin B, an antibiotic used primarily in agriculture (36-37, 22-24). Gentamycin could be measured as low as 80 pg, tobramycin 280 pg, netilmicin 300 pg mL. 

The aminoglycosides include streptomycin, neomycin, kanamycin, amikacin, gentamicin, tobramycin, sisomicin, netilmicin, and others. They are used most widely against gram-negative enteric bacteria, especially in bacteremia and sepsis, in combination with vancomycin or a penicillin for endocarditis, and for treatment of tuberculosis. 

Noone P. Sisomicin, netilmicin and dibekacin a review of their antibacterial activity and therapeutic use. Drugs 1984 27 548-... 

A, amikacin Ap, apramycin B, butirosin D, dibekacin G, gentamicin H, hygromycin I, isepam-icin K, kanamycin L, lividomycin N, netilmicin Ne, neomycin P, paromomycin R, ribostamycin S, sisomicin Sp, spectinomycin St, streptomycin T, tobramycin. 

The aminoglycosides include streptomycin, gentamicin, tobramycin, netilmicin, kanamycin, amikacin, sisomicin, neomycin, paromomycin and others. Those are bactericidal antibiotics. This bactericidal activity is concentration dependent in contrast to the... 

Sisomicin (Figure 8.28) is a dehydro analogue of gentamicin C-ia, and is produced by cultures of Micromonospora inyoensis. It is used medicinally in the form of the semi-synthetic A/-ethyl derivative netilmicin (Figure 8.28), which has a similar activity to gentamicin, but causes less ototoxicity. 

Netilmicin Sulfate, USP. Netilmicin sulfate, I -A(-cth)l-sisomicin (Netromycin), is a semisynthetic derivulivc prepared by reductive ethylation of sisomicin. an aminoglycoside antibiotic obtained from Micraiiioiiu pau iiiyoensis. Structurally, sisomicin and netilmicin rc.scniblc gentamicin C . a component of the gentamicin complex. S CHjOH... 

Aminoglycoside antibiotics contain amino sugars in their structure. Deoxystreptamine-containing members are neomycin, framycetin, gentamicin, kanamycin, tobramycin, amikacin, netilmicin and sisomicin. Both streptomycin and dihydrostreptomycin contain streptidine, whereas the aminocycli-... 

Aminocyclitols - This category of antibiotics includes both aminoglycosides and other antibiotics which contain aminocyclitol moieties but no aminosugar. Control or alteration of resistance development and the moderation of toxic effects are the major areas of research interest. A number of newer aminocyclitols, such as amikacin, sisomicin, verdamicin, netilmicin, were undergoing clinical examination, while tobramycin and amikacin became available for medical use.5,6... 

Noninterfering amikacin, amiloride, amoxicillin, ampicillin, cephalexin, doxycycline, ethosuximide, gentamicin, hydrochlorothiazide, netilmicin, phenacetin, phenemal, phen-3d oin, primidone, sisomicin, tetracycline, tobramycin... 

R = H). Sisomicin is produced by Micromonospora inyoesis (24—26). Netilmicin has the chemical name 0-3-deoxy-4-C-methyl-3-(methylamiao)-p-L-arabinopyranos5i-(1 6)-0-[2,6-diamino-2,3,4,6-tetradeoxy-a-D- )3-hex-4-enopyranosyl-(1 4)]-2-deo xy-A -ethyl-D-streptamine. 

Deamino- and 1-deamino-l-hydroxy- analogues in the gentamicin series have been obtained by isolation and synthesis (178—180). These derivatives have weak antibacterial activity, although the 1-epi analogues of gentamicin C, netilmicin, and sisomicin are highly active (180). 

Until now sisomicin and verdamicin have been relatively little modified. The 1-N-acyl derivatives could be obtained under controlled pH conditions. They show activity comparable to that of the parent compound l-ethyl-sisomidn (netilmicin) 241 was obtained through reaction with an excess of acetaldehyde and sodium borohydride Netilmicin shows an improved antibacterial spectrum. The hydrogenation of sisomicin gave 5 -epi-gentamicin Cia 236 (dihydrosisomicin) This simple conversion caused a substantial loss of activity. 

Aminoglycosides Amikacin, Astromicin, Dibel cin, Dihydrostreptomycin, Framycetin, Gentamicin, Isepamicin, Kanamycin, Micronomicin, Neomycin, Netilmicin, Paromomycin, Sisomicin, Streptomycin, Tobramycin... 

Netilmicin is a semisynthetic aminoglycoside antibiotic that is active against gram-negative bacteria. Netilmicin is an ethyl derivative (at the 1-N position of the deoxystreptamine ring) of sisomicin. 

The aminoglycoside sisomicin and its 1-N-ethyl derivative, netilmicin, have been determined in blood and dried blood precolunm derivatization with a-phthalaldehyde and -mercaptopropanoic add and reversed-phases analysis. Dihydrostreptomydn has been used in the exemplification of capillary h.p.Lc.-coaxial continuous flow FAB-m.s.-m.s. in which capillaries independently deliver eluant and FAB matrix to the mjs. source. ... 

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