Singulair

Adverse reactions of zafirlukast (Accolate) include headache, dizziness, myalgia, pain, nausea, diarrhea, abdominal pain, vomiting, and fever. Montelukast (Singulair) administration may cause headache, dizziness, dyspepsia, flu-like symptoms, cough, abdominal pain, and fatigue Adverse reactions seen with the... 

Montelukast (Singulair) is a leukotriene receptor antagonist approved for treatment of seasonal allergic rhinitis. It is effective alone or in combination with an antihistamine. 

LTB4 is a potent bronchoconstrictor, as are several other leukotrienes. A 5-lip-oxygenase inhibitor, Zileuton, is approved for therapy of asthma (though it is not much used for this purpose) as is a leukotriene blocker, montelukast, marketed as Singulair. Singulair is widely used by asthmatics as a preventive for asthma attacks. Certain corticosteroids are employed for the same purpose. Neither montelukast nor the steroids are effective in terminating an established asthmatic attack. Beta agonists are employed for that purpose (see chapter 17). 

Serevent 60 Seroqud 59 Sertraline 61 Setzone 51 Sevelamer 61 Sibutramine 61 Simvastatin 61 Sinemet 82 Sinequan 31 Singulair 50 Sirolimus 61 Skelid 64 Slo-bid 64 Slophyllin 64 Slow Mag 47 SIcw-K 57... 

Until the late 1990s, nearly 3 decades had passed since the introduction of a truly new class of antiasthma drugs having a novel mechanism of action. This situation changed with the introduction of zafirlukast (Accolate) and montelukast (Singulair), cysteinyl leukotriene (CysLT)... 

Top 11-20 brands (all figures in billion) Ogastro/Prevacid (Takeda), 3.5 Effexor (Wyeth), 3.5 Procrit/Eprex (Johnson Johnson), 3.3 MabThera/Rituxan (Roche), 3.3 Zoloft (Pfizer), 3.3 Fosamax (Merck), 3.2 Singulair (Merck), 3 Cozaar+Hyzaar (Merck), 3 Seroquel (AstraZeneca), 2.8 Remicade (Johnson Johnson), 2.5 Lovenox (Sanofi-Aventis), 2.7. 

Effexor 3.5 Nexium 4.6 Cozaar/ — Taxotere 2.0 Zyprexa 4.2 Singulair 3.0... 

Singulair Montelukast sodium Merck Oral granules Granule... 

It makes Cozaar and Hyzaar for hypertension Vytorin, Zetia, and Zocor to lower cholesterol Pro-pecia for male-pattern baldness Singulair for asthma Fosamax for osteoporosis and Gardasil, a vaccine for cervical cancer but it is also well known for making Vioxx, a pain relief drug taken off the market for causing heart problems. 

There is also continuous interaction throughout the review process. For example, over roughly six years, the sponsor, Merck Research Laboratories of West Point, Pa., and the FDA had several face-to-face meetings and about 28 teleconferences regarding the asthma drug Singulair (montelukast sodium). 

USAN- Montelukast sodium Trade Name Singulair Merck... 

Figure 13.29 Ketone reduction by whole cells of yeast Montelukast (Singulair ) Montelukast (Singulair )n (Shafiee, 1998b).

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