Single-unit containment system

The ER formulations can be a single-unit, monolithic system or multiple-unit systems containing many individual units with extended release. Multiple-unit systems consist of many small pellets and are normally produced by extrusion and spheronization or coating on inert spheres [2,10]. The composition and ER mechanism can vary for multiple-unit systems, and some examples are membrane-coated reservoir systems and polymer- or lipid-based matrix systems, where the matrices can be made of both soluble and insoluble carriers [11-16]. 

Single unit containment, with a dousing system for pressure suppression, as used in CANDU 6... 

The physical form of the thermocouples varies significantly according to appHcations. Most spacecraft power suppHes utilize separate thermocouples that can be checked for performance at successive stages of manufacturing and be replaced if necessary. This approach fits in very well with the extremely high rehabihty requirements imposed on such systems. In terrestrial systems where such individualized attention is not economically feasible, modular assembhes are generally used, which can contain tens to hundreds of couples in a single unit. 

A change from a single unit dose container to a multiple dose container system. 

Cyclopentadienyl systems bridged by a single silicon-containing unit are described in Section II.E.l. Cyclopentadienyl units which are held together by a double bridge are described in Section II.E.2. Section II.E.3. describes cooperative effects exerted by dimethylsilyl groups as bridging units, with special emphasis on polyferrocenyl compounds. 

Power Supply and Process Control Unit. Electrodialysis systems use large amounts of direct current power the rectifier required to convert AC to DC and to control the operation of the system represents a significant portion of a plant s capital cost. A typical voltage drop across a single cell pair is in the range 1 -2 V and the normal current flow is 40 mA/cm2. For a 200-cell-pair stack containing 1 m2 of membrane, the total voltage is about 200-400 V and the current about... 

Figure 2-29 Raman Systems Model R2001 from Ocean Optics. Both the laser and the spectrometer are contained in the single unit. (Reproduced with permission from Ocean Optics.)...

Systems with Capsular Structure Several single-unit pulsatile dosage forms with a capsular design have been developed. Most of them consist of an insoluble capsular body which contains the drug and a plug which is removed after a predetermined lag time because of swelling, erosion, or dissolution. 

Multiporous oral drug absorption system. A single-unit, immediate-release tablet formulation consisting of an inner core, containing active drug plus excipients, surrounded by a non-disintegrating, timed release coating. 

Similar to containers, closures can be viewed as applying either to single-unit or multiple-unit containers. While single-unit closures can be designed to be destroyed during use, multiple-unit closures may be used many times while drug product remains in the container. Consequently, the requirements for a closure system can be somewhat conflicting. The ideal... 

Closure systems typically refer to the closures on multiple-unit containers. The closure may consist of a single-use film or barrier underneath an enclosable cap or plugged to be replaced for subsequent use. 

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