Single-chain nanoparticles

Figure 4.7 AFM images of single-chain nanoparticles. Panels A and B are on mica, while panels C and D are on graphite.

Fu X, Wang Y, Huang L, Sha Y, Gui L, Lai L, Tang Y. Assemblies of metal nanoparticles and self-assembled peptide fibrils—formation of double helical and single-chain arrays of metal nanoparticles. Adv Mater 2003 15 902-906. 

Gerdon et al. [84] have combined a sensitive QCM system with protein A-mediated antibody presentation and antigen-coated nanoparticles in the fluid phase. Shen et al. [85] have recently developed a QCM-based nonlabeled biosensor ( piezoimmunosen-sor ) with a modified single-chain antibody on its surface. It exhibited high selectivity, sensitivity, and stability and was also regenerable for at least one cycle of reuse. 

Advances in click chemistry for single-chain polymeric nanoparticle construction 13MOL3339. 

Meijer et al. [64] described an unusual strategy to obtain metastable supramolecular polymer nanoparticles. Each nanoparticle arose from the collapse of a single polymer chain. This approach relied on a PNBE chain functionalized with a photoactivable quadruple hydrogen-bonding unit, which is able to create intramolecular cross-linking of single chains after deprotection. 

---