Single-chain nanoparticles chemistry

Advances in click chemistry for single-chain polymeric nanoparticle construction 13MOL3339. 

The main inspiration for the formation of nanoparticles from single amino acids arose from the fact that in nature, many particles are formed from short chain peptides that contain a cysteine or histidine amino acid. These short chain peptides are principally used as a form of detoxification from the effects of high heavy metal ion concentrations in vivo. From these biological examples, the chemistry of these peptides has been expanded to form novel zero-valent and semiconductor nanoparticles under in vitro conditions (Figure 2). 

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