Simian virus promoter

Nakanishi, A., Clever, J., Yamada, M., Li, P.P. and Kasamatsu, H. (1996) Association with capsid protein promotes nuclear targeting of simian virus 40 DNA. Proc. Natl. Acad. Sci. USA, 93, 96-100. 

Promoters from cytomegalovirus (CMV) or simian virus 40 (SV40) have been widely used because they are known to be strong promoters (Qin et al., 1997). When we evaluated mouse interleukin-4 (IL-4) and interleukin-10 (IL-10) expres-sion plasmids, pCMV-mIL-4 and pCMV-mIL-10, respectively, we found a high expression level of IL-4 or IL-10 in vitro and in vivo Koh et al. (2001). However, CMV promoter appears to show a decrease in activity when administered in vivo. The duration of gene expression by CMV promoter is short compared with cellular promoters such as j3-actin promoter. Also, CMV promoter shows lower activity than chicken P-actin promoter in the liver (Xu et al., 2001). 

Fromm M, Berg P (1983), Simian virus 40 early- and late-region promoter functions are enhanced by the 72-base-pair repeat inserted at distant locations and inverted orientations, Mol. Cell. Biol. 6 991-999. 

Gilinger, G., Alwine, J. C. (1993) Transcriptional activation by simian virus-40 large T-Antigen - requirements for simple promoter structures containing either TATA or initiator elements with variable upstream factor binding sites. J Virol 67, 6682-6688. 

Segment of the simian virus 40 (SV40) genome that contains an origin of replication plus a powerful promoter sequence. 

Gruss, P., Dhar, R., and Khoury, G., 1981, Simian virus 40 tandem repeated sequences as an element of the early promoter, Proc. Natl. Acad. Sci. USA 78 943-947. 

Mammalian plasmid-based vectors, in addition to a prokaryotic replicon and a selection marker to permit DNA replication in E. coli, commonly have a eukaryotic replicon and a eukaryotic selection marker. The replicon usually comes from viruses such as Simian virus 40 (SV40), bovine papilloma virus (BPV) or Epstein Barr virus (EPV). The commonly used promoters are the SV40 early promoter (including its upstream enhancer... 

Fig. 16.6 Prosthetic gene networks. (A) Selfsufficient synthetic circuit to control blood-urate homeostasis. (B) Obesity treatment. (C) Diabetic ketoacidosis treatment (D) Artificial insemination. cAMP, cyclic adenosine monophosphate CREBl, cAMP-responsive element binding protein 1 KRAB, Kriippel associated box LHR, luteinizing hormone receptor TtgR-specific operator promoter activated by CREBl human cytomegalovirus promoter hEFia elongation factor 1 alpha promoter, P, simian virus 40 promoter PPARa, human...

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