Simian virus mRNAs

Thus, in some cells, parental histones appear to be inherited directly. Simian virus 40 may be an exception. When DNA synthesis ceases at the end of the S phase, any histone mRNA is rapidly degraded. This link between DNA synthesis and histone synthesis may serve as a feedback mechanism to ensure that the amount of new histone formed is consonant with the amount of new DNA synthesized. 

Graessmann, M., and Graessmann, A. (1982) Simian virus 40 cRNA is processed into functional mRNA in microinjected monkey cells. EMBO J. 1, 1081-108 ... 

Swimmer, C., and Shenk, T, 1985, Selection of sequence elements that substitute for the standard AATAAA motif which signals 3 processing and polyadenylation of late simian virus 40 mRNAs, Nucleic Acids Res. 13 8053-8063. 

Hiebert, S. W., Peterson, R. G., and Lamb, R. A., 1985, Hemagglutinin-neuraminidase protein of the paramyxovirus simian virus 5 Nucleotide sequence of the mRNA predicts an N-terminal membrane anchor, J. Virol. 54 1-6. 

The outcome of infection by SV40 depends on the organism infected. When simian cells are infected, the virus enters the cell and loses its protein coat. The viral DNA is expressed first as mRNAs and then as proteins. The large-T protein is the first one made (Figure 14.6), triggering the replication of viral DNA, followed by viral coat proteins. The virus takes over the cellular machinery for both replication of DNA and protein synthesis. New virus particles are assembled, and eventually the infected cell bursts, releasing the new virus particles to infect other cells. 

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