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Silver-NHC Complexes as Anticancer Agents

The mechanism of action of silver(I) NHC complexes as anticancer agents is stiU not well defined. However, there are some studies indicating that silver(I) NHC complexes with poly-NHC Hgands show in vitro antiprohferative activity higher or at least comparable with as-platin. For example, Willans and coworkers have reported the in vitro antiproliferative activity of a series of mono- and dinuclear silver(I) di-NHC complexes on MCF7 (human breast adenocarcinoma) and DLDl (human colon... [Pg.268]

A small number of non-NHC silver compounds have been studied as potential anticancer agents. Berners-Price and coworkers synthesized bischelated silver(I) diphosphine and pyridiyl phosphine complexes, which proved to have in vitro cytotoxic properties against a variety of cancer cell lines tested, including cis-platin-resistant lines [28,29]. Additionally, a series of coordination polymers... [Pg.187]

See other pages where Silver-NHC Complexes as Anticancer Agents is mentioned: [Pg.187]    [Pg.187]    [Pg.189]    [Pg.189]    [Pg.193]    [Pg.187]    [Pg.187]    [Pg.189]    [Pg.189]    [Pg.193]    [Pg.194]    [Pg.614]    [Pg.187]    [Pg.192]    [Pg.193]    [Pg.268]    [Pg.605]    [Pg.607]    [Pg.608]   


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Anticancer agents

Anticancer agents, complexes

As anticancer agent

Complexation agent

Complexation complexing agents

NHC complexes

NHC-silver complexes

Silver complexes

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