Silicone transdermal patches

Solid PIBs are used in plasticized formulations. In the drag containing adhesive of transdermal patch, 10-40 wt% plasticizer (mineral oil, silicone oil, octyl palmitate, etc.) is added to plasticize material and impart hydrophobic properties. Petrolatum or mineral oil was used in adhesive skin barrier which is a pressure sensitive adhesive based on... [Pg.309]

Transdermal drug-delivery systems offer several important adventages over more traditional approaches, in addition to the benefits of avoiding the hepatic first-pass effect. Transdermal drug delivery systems (TDDS) are usually in the form of patches incorporating pressure sensitive adhesives. There are two basic designs for transdermal patches matrix or reservoir type. Matrix-type patches include monolithic adhesive and polymer matrices, whereas reservoir-type patches include liquid and solid-state reservoirs [71-73]. For various types of transdermal delivery systems, medical grade adhesive silicones are used as [73,74] ... [Pg.377]

III. Group Silicone elastomers intended for medical use on skin, e.g., transdermal delivery system, patches, medical use [25-32] ... [Pg.368]