Significance threshold

Cheng C et al (2004) Statistical significance threshold criteria for analysis of microarray gene expression data. Stat Appl Genet Mol Biol 3 Article36. doi 10.2202/1544-6115.1064... 

More than one protein present in the sample with good-quality PMF data, mixtures containing two to three proteins can be identified, but the presence of peptide masses from the other proteins reduces the score for each individual match. With lower-quality data, this can result in all of the scores dropping below the significance threshold. The presence of contaminants, e.g., trypsin or keratins, has the same effect however, known peptide masses derived from keratins and trypsin can be removed from the PMF data prior to searching (9). 

Use the default parameters (except the number of alignments and descriptions) such as nr as the database (see Note 3), e-value 10 and the statistical significance threshold to include a sequence for generating the PSSM for the next iteration as 0.005. Change the maximum number of alignments and descriptions, 1000, from the respective pull down menus to retrieve possibly all statistically significant hits. 

No significant peaks (positive or negative) should remain in difference electron density maps, whereby a pragmatic defirution of a significance threshold will lie somewhere between 4.5 and 5 a (where a is the r.m.s.d. of the IFo — IFc difference electron density map). Remaining peaks are acceptable if a plausible interpretation such as probably a third conformation of a Ser, but not modeled can be given. 

Phenotype Initial samples Repheation samples Number of loci identified Significance threshold Reference... 

The significant threshold in objectives under RTCA/DO-178C is from Level D to Level C. This is because the objectives fundamental to assuring the validity and satisfaction of SAV requirements, including safety requirements, are incorporated at Level C. This is achieved by the following ... 

An alarm system component such as a beU, buzzer, horn, speaker, light, or text display that provides an audible, visible, or tactile output to announce a condition of concern. Significant Threshold Shift (STS)... 

Proteins in the database are ranked in order of best correlation, usually with a significance threshold based on a minimum number of peptides matched. 

For weakly wetted systems, the mobilization process appears to occur as follows. The receding surface first begins to move through the throat increasing the pressure drop across the advancing surface then, a jump of the advancing surface (which requires a significant threshold force) rapidly follows. This behavior could not have been identified from capillary-type experiments. 

The available experimental data on reactions with a significant threshold suggest that cross sections are <0.05 nm, as found in the C+ + Dg system. A theoretical study of the tritium-deuterium reaction... 

Next in the analysis is performing unadjusted association tests between genotypes and linear regression for serum levels and baselines. Tests wiU be performed on each marker, and markers that clear a significance threshold of p <. 05 are selected for permutation testing. 

Significance thresholds In comparative LCA, the uncertainty of the results and the importance of the differences in the results can be taken into account by distinguishing between significance thresholds. Has any approach of this type been applied ... 

Table 13.16 Significance thresholds used in an LCA study on biodegradable polymers [17] ...

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