Signal Transduction Knowledge

Signal Transduction Knowledge Environment (STKE). Science Magazine, AAAS. URL http //stke.sciencemag.org/. A weekly electronic journal on cell signaling. 

The Signal Transduction Knowledge Environment (table 7.1) is another expert-curated database, focusing exclusively on signaling pathways. It currently contains about 40 detailed and annotated pathway descriptions, including citations and graphical connection maps. Originally a collaboration between Stanford University and the journal Science, it is now available by subscription. 

STKE Signal transduction knowledge environment http //stke.org/... 

Andrews, S., Stephens, L.R., and Hawkins, P.T. (2007) PI3K class IB pathway in neutrophils. Science s STKE Signal Transduction Knowledge Environment, 2007, cm3. 

Shenoy, S.K. and Lefkowitz, R.f. (2005) Seven-transmembrane receptor signaling through beta-arrestin. Science s STKE Signal Transduction Knowledge Environment, 2005, cmlO. 

Heit, B. and Kubes, R, Measuring chemotaxis and chemokinesis the under-agarose cell migration assay Science s STKE [electronic resource] signal transduction knowledge environment. 2003, 2003 PL5. 

Ral has attracted much interest in recent years, not least because it was demonstrated to mediate part of Ras function as described above. In contrast to Rap, which rather inhibits Ras signaling, Ral is part of one of the essential Ras-activated pathways. Moreover, it has proved to be acting in parallel with the Raf pathway in cell transformation induced by oncogenic Ras [37, 77]. The case of Ral demonstrates the complexity - and the incomplete knowledge and understanding - of signal transduction. Ral can also be activated by Rap mediated by Rif [103] and, alternatively, by binding of a calcium/calmodulin complex to the Ral C-terminus which obviously does not affect the nucleotide state of Ral [111]. 

With their newly accorded significance in signal transduction and membrane studies, the increase in knowledge about phospholipases has been remarkable. 

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