Signal transduction cycle protein

Fig. 3. The G-protein dependent signal transduction cycle. The signal transduction unit is represented by R (receptor), G (G protein), and E (effector). G is composed of Ga wifh bound GTP or GDP and of GPy. The acfive and inactive complexes or proteins are shown in black and grey, respectively. S represents the stimulus that triggers the cycle. Proteins interacting in a complex ore linked by hyphens...

The SCF and SCF-like complexes are multi-subunit RING-type E3s that represent the largest E3 family knotvn to date. This superfamily of E3s are involved in regulating cell-cycle progression, signal transduction pathways, transcriptional control, and multiple aspects of cell growth and development (reviewed in Ref. [50]). All members of this E3 superfamily contain two basic components, a member of the cullin protein family and a RING-domain protein. The cullin subumt serves as the... 

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