Signal peptide sequence

There are 17 human type I IFN genes, all clustering on chromosome 9. They are intronless and encode secretory signal peptide sequences that are proteolytically cleaved prior to secretion from the cell. Type I IFNs are genetically and structurally closely related. They range in length from 161 to 208 amino acids and have apparent molecular weights of 15-24 kDa (Table 1) (Chen et al. 2004). The different subtypes of human IFN-a have approximately 50% amino acid sequence identity, whereas IFN-a shares approximately 22% amino acid identity with human IFN-p and 37% with human IFN-m (Chen et al. 2004). 

McGeoch, D. (1985). On the predictive recognition of signal peptide sequences. Virus Res. 3, 271-286. 

The ovalbumin gene, shown here, has introns A to G and exons 1 to 7 and L (L encodes a signal peptide sequence that targets the protein for export from the cell see Fig. 27-34). About three-quarters of the... 

Fernandez, C., Gregory, W.F., Loke, P. and Maizels, R.M. (2002) Full-length-enriched cDNA libraries from Echinococcus granulosus contain separate populations of oligo-capped and trans-spliced transcripts and a high level of predicted signal peptide sequences. Molecular and Biochemical Parasitology 122, 171-180. 

Translation of presecretory proteins Post-translational precursor processing Removal of the signal peptide sequence Signal peptidase activity... 

Polypeptide lengths refer to mature proteins, as predicted from cDNA sequences, after removal of cleavable signal peptide sequences. Natural IFN proteins may undergo C-terminal processing so that shorter forms may be generated. 

Proteolytic processing. Several cleavage reactions may occur. These include removing the formylmethionine residue and signal peptide sequences. (Signal peptides, or leader peptides, are short peptide sequences, typically near the amino... 

Signal Peptide Sequences Direct Protein Targeting... 

The major function of signal peptide sequences in proteins is to... 

In addition to proteolytic processing (i.e. removal of the signal peptide sequence), the polypeptide is subject to other covalent modifications N- and 0-glycosylation and 0-phosphorylation. After synthesis and transportation across the ER lumen, the proteins pass to the Golgi apparatus and thence,... 

Hawiger has developed CPPs derived from the membrane-translocating hydro-phobic sequence of the h-region of the signal peptide sequence of K-FGF [88]. 

Pre-proprotein a precursor in the biosynthesis of a secretory protein (see Signal hypothesis). The P-p. possesses an Af-terminal signal peptide sequence in addition to the proprotein sequence, e.g. pre-proinsulin, pre-protrypsin, pre-proparathormone, pre-pro-mellitin, etc. 

Preprotein the biosynthetic precursor of a secretory protein containing a very short-lived signal peptide sequence (see Signal hypothesis), e.g. preovomucoid and prelysozyme. 

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