Side effects of risperidone

Insomnia, hypotension, agitation, headache, and rhinitis are the most common side effects of risperidone. These tend to lessen with time. Overall, the drug tends to be well tolerated. Average weight gain associated with risperidone after 10 weeks of treatment is 2.10 kg (AUison et al. 1999). Risperidone does not have significant anticholinergic side effects. Hyperprolactinemia is common. 

Edwards RJ, Pople IK. Side-effects of risperidone therapy mimicking cerebrospinal fluid shunt malfunction implications for clinical monitoring and management. J Psychopharmacol 2002 16(2) 177-9. 

Peitl MV, Peitl V, Grahovac T, Pavlovic E. Galactorrhea—side effect of risperidone in combination with Depakine Chrono in a patient with bipolar disorder. Psychiatr Danub 2010 22 125-7. 

Giine F, Batgi H, Akbal A, Canatan T. Angioedema - an unusual serious side effect of risperidone injection. Clin Toxicol 2013 51(2) 122-3. 

Risperidone and its active metabolite 9-OH-resperidone are metabolized by CYP2D6. Polymorphic metabolism should be considered in those with side effects at low doses (approximately 40% of African Americans and Asians can have increased side effects from risperidone and other drugs metabolized through CYP2D6). 

Given that limitation, the only ways to counteract elevated prolactin are to lower the dose of the antipsychotic or to switch to another antipsychotic that does not elevate prolactin. We prefer switching (especially if the problem has been encountered with an older style typical antipsychotic) to an atypical antipsychotic if side effects of elevated prolactin become problematic. Most atypical antipsychotics, with the exception of risperidone when used in high doses, do not elevate prolactin. There are few compelling reasons to use a typical antipsychotic compared to the newer atypical agents. 

Atypical antipsychotics cause fewer EPS than do conventional antipsychotics. Clozapine and quetiapine are the least likely to cause EPS and are therefore recommended for treatment of psychosis in patients with Parkinson s disease. With the notable exception of risperidone, atypical antipsychotics cause substantially less hyperprolactinemia than do conventional antipsychotics. Weight gain is a side effect of all atypical antipsychotics except ziprasidone and aripiprazole. Concerns about cardiac conduction delay with ziprasidone therapy exist and warrant consideration in patients who have... 

Leucht S, Pitschel-Walz G, Abraham D, Kissling W. Efficacy and extrapyramidal side-effects of the new anti-psychotics olanzapine, quetiapine, risperidone, and sertin-dole compared to conventional antipsychotics and placebo. A meta-analysis of randomized controlled trials. Schizophr Res 1999 35(1) 51—68. 

Since the release of clozapine, researchers have sought to develop an atypical antipsychotic without the side effects of clozapine (especially aplastic anemia). As of this writing, two other atypical agents have been released risperidone and olanzapine, and several others may soon be released, including sertindole and quetiapine. These agents vary somewhat in their pharmacological profile and, as a group, may... 

ARIPIPRAZOLE, CLOZAPINE, HALOPERIDOL, PERPHENAZINE, RISPERIDONE, SERTINDOLE SSRIs Possible t plasma concentrations of these antipsychotics Inhibition of CYP2D6-mediated metabolism of these drugs. The clinical significance of this depends upon whether alternative pathways of metabolism of these substrates are also inhibited by co-adminis-tered drugs. The risk is theoretically greater with clozapine, haloperidol and olanzapine because their CYPl A2-mediated metabolism Is also Inhibited by SSRIs Warn patients to report T side-effects of these drugs, and consider reducing the dose of the antipsychotic... 

Unknown mechanism (betel nut worsens the side-effects of flupentixol and fluphenazine). Ginkgo may t haloperidol effects. Kava kava t side-effects of haloperidol and risperidone... 

Kava kava T side-effects of haloperidol and risperidone... 

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