Side chain effect

Wu, C.W., Sanborn, T.J., Zuckermann, R.N., and Barron, A. E. Peptoid oligomers with alpha-chiral, aromatic side chains Effects of chain length on secondary structure. /. Am. Chem. Soc. 2001, 723, 2958-2963. 

H.-Z. Tang, M. Fujiki, and M. Motonaga, Alkyl side chain effects of optically active polyfluorenes on their chiroptical absorption and emission properties, Polymer, 43 6213-6220, 2002. 

Fandrich, M., and Dobson, C. M. (2002). The behaviour of polyamino acids reveals an inverse side chain effect in amyloid structure formation. EMBOJ. 21, 5682-5690. Fandrich, M., Fletcher, M. A., and Dobson, C. M. (2001). Amyloid fibrils from muscle myoglobin. Nature 410, 165-166. 

SIDE-CHAIN EFFECTS IN OTHER AMINO ACIDS... 

FIGURE 1.4 Side-chain effects in other amino acids. 

This effect was seen only in hypoxia, not normoxia, was dose-dependent within the range 0.2-200 /rM, and provided a simple in vitro model for investigating the mode of action of the vitamin. By examining the structure-activity relationship of the response, compounds with a phytyl side-chain, phytol and vitamin K-l (phytomenadione), of similar length to vitamin E (9) were found to be also active, but compounds that had structures which resembled the chroman ring of the vitamin, vitamin K-3 (menaphthone) and Trolox, were antagonists of the responses to the phytol side-chain effects. 

Fig. 11 Poly(L-glutamic acid) incorporating 85 mol% spiropyran units in the side chains. Effect of irradiation on CD spectra in various HFP/MeOH solvent mixtures in the presence...

Scheme 24 Side-chain effects on the selectivity of the mono-S-oxidation of penems.

Side Chain Effect Effects Solvent Effect... 

Sherwood number, 56, 59 Shielding constant, 368 Shift factor, 443 Shish kebab structure, 705, 731 Shore D hardness, 831 Shore hardness testers, 838 Short-range order, 25 Short shots, 804 line region, 807 Short-term behaviour, 820 Short-time stiffness, 25 Side chain effects, 184 Significance of the shift factor, 450 Silky lustre, 876 Simha/Boyer rule, 100... 

The IR study of these peptides in CDCl3 solution at high dilution showed that a much higher content of intramolecularly hydrogen-bonded forms exist in (Ala)4 than in (Val)4 peptides. At higher concentrations, chain length, solvent, and side chain effects are all operative in determining the extent of peptide association in these... 

The question as to possible differences in conformation between the apo and Ca(II)-bound forms of a-lactalbumin was also addressed by Kuwajima et al. (1986), who found that the Ca(II)-bound and free fo.r ns can assume essentially the same folded conformation, as evidenced by similarity in their CD and proton NMR spectra. However, on the basis of CD studies of aromatic side-chain effects, they concluded that the stability of the folded state is markedly enhanced by Ca(II). 

The curves in this region cannot be classified simply as typical of mammalian lysozymes, egg lysozymes, and a-lactalbumins. The spectra for bovine, pig, and kangaroo a-lactalbumins are very similar. On the other hand, the curve for human a-lactalbumin is similar to that for human lysozyme, but different from that of domestic hen lysozyme. The curve for echidna lysozyme I resembles that of human lysozyme fairly closely. The side-chain effects of red kangaroo a-lactalbumin and echidna lysozyme I resemble those of human lysozyme (Hopper and McKenzie, 1974). 

Emzerhof M, Zhuang M, Rocheleau P. Side-chain effects in molecular electronic devices. J. Chem Phys. 2005 123 134704. 

Fandrich M, Dobson CM (2002) The behavior of polyamino acids reveals an inverse side chain effect in amyloid structure formation. EMBO J 21 5682-5690... 

Pleus, S., and Schulte, B. 2001. Poly(pyiToles) containing chiral side chains Effect of substituents on the chiral recognition in the doped as well as in the undoped state of the polymer film. Journal of Solid State Electrochemistry 5. 522-530. 

Our results are in complete accord with the suggestion that amyloid structures may arise from the generic properties of the proteins, with the details of the amino-acid side chains playing a secondary role. However, our work suggests that instead of an inverse side chain effect in amyloid structure formation [63], there is a unifying theme in the behavior of proteins. Just as the class of cross-linked [3-structures... 

L-alanine content (between 20 and 30%), any significant changes in chemical shift change was observed for chemical shift changes may be mainly due to the side-chain effect of the L-valine residue and the neighbouring amino acid sequence effects, but apparently are not due to the main-chain conformation of copolypeptides. 

Figure 6.2.15 Crystal structure of the usual P-substituted porphyrin dimers with (a) shifted, unrotated porphyrin planes, (b)a P-alkyl chain, and (c) acid side-chain effects.

Abe, H. and Doi, Y B/oraacwmo/e. 2002, 3/7/, 33- 3i. Side-Chain Effect of Second Monomer Units on Crystalline Morphology, Thermal Properties, and Enzymatic Degradability for Random Copolyesters of (R)-3-Hydroxybutyric Acid with (R)-3-Hy-droxyalkanoic Acids. 

---