Sialyltransferases ganglioside-specific

More recently, studies on Campylobacter jejuni have demonstrated how specific bacterial carbohydrate antigens can mimic the fine structure of human cell surface glycolipid structures and elicit autoimmune reactivity. Yuki et al.61 first identified that the lipooligosaccharide (LOS) of C. jejuni mimicked human G(M)1 ganglioside and subsequently extended these studies to demonstrate that specific single amino acid variants of the C. jejuni Cst-II sialyltransferase protein are responsible for the synthesis of LOS variants that in turn, mimic different... 

The receptor specificity of Sendai vims was first analyzed in studies employing gangliosides [136, 137] and erythrocytes that contained defined sialyloligosac-charides after neuraminidase and subsequent sialyltransferase treatment [138]. These studies showed that Sendai vims has a preference for a2-3-bound... 

Iber, H., Vanechten, G., and Sandhofif, K., 1991, Substrate specificity of a2-3-sialyltransferase in ganglioside biosynthesis of rat liver Golgi, Eur. J. Biochem. 195 115-120. 

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