Sialic acid, recognition

Brinkman-Van der Linden, E. C., Sjoberg, E. R., Juneja, L. R., Crocker, P. R., Varki, N., Varki, A. (2000). Loss of A-glycolylneuraminic acid in human evolution implications for sialic acid recognition by siglecs. J. Biol. Chem., 275, 8633-8640. 

Kraschnefski MJ, Bugarcic A, Fleming FE, Yu X, von Itzstein M, Coulson BS, Blanchard H (2009) Effects on sialic acid recognition of amino acid mutations in the carbohydrate-binding cleft of the rotavirus spike protein. Glycobiology 19 194-200... 

Luo Y, Li SC, Chou MY, Li YT, Luo M (1998) The crystal structure of an intramolecular trans-sialidase with a NeuAc alpha2->3 Gal specificity. Structure 6 521-530 Moustafa I, Connaris H, Taylor M, Zaitsev V, Wilson JC, Kiefel MJ, von Itzstein M, Taylor G (2004) Sialic acid recognition by Vibrio cholerae neuraminidase. J Biol Chem 279 40819 0826... 

Sialic Acid Recognition by the Immunoglobulin Fold— Evolutionary Considerations... 

Structure of Receptor Binding Domain and Mechanism of Sialic Acid Recognition... 

Gal/GalNAc or Man/GlcNAc, there are also receptors (e.g., the macrophage sialic acid receptor) for the recognition of sialylated complex glycans.10... 

The sensors discussed so far are based on ligands covalently bound to the polymer backbone. Other methods of detection - often referred to as mix and detect methods - work by simple noncovalent incorporation of the polymer with the ligand of interest. Reichert et al. generated liposomes of polydiacetylene with sialic acid for the same purpose of detection as Charych s surface-bound polymers, but realized that covalent functionalization of the polymer was not necessary [17]. Through simple mixing of the lipid-bound sialic acid with the polymer before sonication and liposome formation, they were able to form a functional colorimetric recognition system (Fig. 8). 

Fig. 10.36. Recognition of uronic and sialic acid salts by the cooperative action of boronic acid and zinc chelate (Yamamoto M. et al. (1996) Tetrahedron 54, 3125).

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