SIADH inappropriate secretion

Loss of blood glucose control When a patient stabilized on any diabetic regimen is exposed to stress such as fever, trauma, infection, or surgery, a loss of control may occur. At such times, it may be necessary to discontinue the drug and give insulin. Disulfiram-like syncframe. A sulfonylurea-induced facial flushing or breathlessness reaction may occur when some sulfonylureas are administered with alcohol. Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) Water retention and dilutional hyponatremia have occurred after administration of sulfonylureas to type 2 diabetes patients, especially those with CHF or hepatic cirrhosis. 

BUN, blood urea nitrogen CBC, complete blood cell count CBZ, carbamazepine DVP, divalproex sodium EKG, electrocardiogram SIADH, syndrome of inappropriate secretion of antidiuretic hormone TSH, thyroid-stimulating hormone. 

Note. SIADH=syndrome of inappropriate secretion of antidiuretic hormone CBC=complete blood count TSH=thyroid-stimulating hormone ECG=electrocardiogram AST=aspartate aminotransaminase ALT=alanine aminolransaminase. 

The main dose-limiting toxicity is neurotoxicity, usually expressed as a peripheral sensory neuropathy, although autonomic nervous system dysfunction with orthostatic hypotension, urinary retention, paralytic ileus, or constipation, cranial nerve palsies, ataxia, seizures, and coma have been observed. While myelosuppression occurs, it is generally milder and much less significant than with vinblastine. The other potential adverse effect that can develop is the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). 

There has been a single case report of inappropriate secretion of antidiuretic hormone (SIADH) attributed to mizoribine (725). 

The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) (728) may be the mechanism of action underlying cases of peripheral edema that have been described (SEDA-2, 12 SEDA-6, 28). Diuretics are not helpful, but dosage reduction produces relief (729). 

A rare but well-known adverse effect of vinca alkaloids, including vinorelbine, is the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) (1195-1197). The diagnosis is usually based on clinical and laboratory... 

The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a possible adverse effect of the SSRIs (SEDA-14, 14) (SEDA-18, 20) (SEDA 21, 11) (40). The mechanism is not known. Several of the affected patients have been elderly, and old people may be at greater risk. 

The syndrome of inappropriate secretion of antidiuretic hormone secretion (SIADH) maybe treated with frusemide if there is a dangerous degree of volume overload, (see also p. 713). 

SIADH syndrome of inappropriate secretion of ADH TSH thyroid-stimulating hormone... 

Inappropriate secretion of antidiuretic hormone (SIADH) (2006) Yoshikawa S +, J Cardiol 48(4), 215 (2004) Aslam MK+, Pacing Clin Electrophysiol 27(6 Pt I), 83 I Pseudoporphyria... 

Acute intermittent porphyria (1984) Doss M +, Lancet I, 1026 (1983) LiawahAC +, Lancet I, 1442 Inappropriate secretion of antidiuretic hormone (SIADH)... 

Inappropriate secretion of antidiuretic hormone (SIADH) Pseudoporphyria... 

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