Shwartzman reaction

The endotoxlc activity associated with Gram-negative bacterial infections resides in the lipophilic lipid A part of the LPS molecule (1). This toxic activity manifests itself in a number of ways, e.g., pyrogenicity, transient leucopenla followed by leucocytosis, hypotension, bone marrow necrosis, abortion, the Shwartzman reaction, etc. As a consequence the commonly used killed whole cell enterobacterial vaccines have to be given in... 

TNFa is primarily responsible for a laboratory phenomenon known as the localized hemorrhagic Shwartzman reaction in which repeated injection of LPS into a solid tissue leads to hemorrhagic infarction. This occurs because LPS-induced TNFa secretion by macrophages can stimulate endothelial ceils to release PGs, IL-6, and other mediators that cause coagulation, clotting, and obstruction of local blood supply,... 

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