Shellfish poisons pharmacology

IPC is also effective for pharmacology related to brain disease. It was used to analyze picolinic acid and related compounds [90], neurotoxins associated with paralytic shellfish poisoning [91], a drug candidate for treating Alzheimer s disease [92], and nicergoline, clinically used for improving brain metabolism [93]. Quaternary ammonium anticholinergics were determined in whole blood and the matrix effect was taken into account [94]. 

Suarez-Isla, B.A. and Velez, P, Paralytic shellfish poisoning. Biological detection methods, m Seafood and Freshwater Toxins Pharmacology, Physiology and Detection (ed. Botana, L.M.). Marcel Dekker, New York, 2000, p. 187. 

The main symptom of DSP, after which the poisoning is named, is represented by diarrhea, often associated with other gastrointestinal distresses such as nausea, vomiting and abdominal cramps. Usually, these symptoms occm within 30 min to a few hours after contaminated shellfish consumption. In general, no hospitalization of the patients is necessary and, usually, there is a complete recovery within 3 days without any pharmacological treatment. In fact, no specific antidote is available for diarrheic toxins, to date. The treatment, if necessary, is only supportive to replace fluid and electrolyte losses. Although no lethality is attributed to the diarrheic episodes, they represent a worldwide problem to both public health and bivalve production and marketing. ... 

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