Serum IgE levels

About 90% of all asthmatics have increased serum IgE levels and suffer from Type I allergy, called extrinsic (allergic) asthma. 

Role of Adaptive Immune Responses in Atopic Dermatitis Involving IgE Responses In about 80% of adult patients with atopic dermatitis, the disease is associated with increased serum IgE levels, sensitization against aeroallergens... 

Further assessment of atopy in the pathogenesis of the acute byssinotic reaction necessitates purification of well characterized and standardized cotton dust antigens, and the development of an allergy specific test (HAST) to measure serum IgE antibodies to cotton dust allergens. Such developments would allow correlation of skin tests, clinical history, dust exposure, FEVj and serum IgE level with specific IgE to cotton dust allergens. 

Pretreatment Serum IgE Levels (units/ml) Weight 30-60kg Weight 61-70 kg Weight 71-90 kg Weight 91-150 kg... 

Total IgE levels are elevated during treatment and remain elevated for up to 1 yr after the discontinuation of treatment re-testing of IgE levels during omalizumab treatment cannot be used as a guide for dose determination dose determination after treatment interruptions last ing < 1 yr should be based on serum IgE levels obtained at the initial dose determination... 

Omalizumab is an anti-IgE recombinant humanized monoclonal antibody that is approved for the treatment of allergic asthma in adult and adolescent patients whose symptoms are refractory to inhaled corticosteroids (see Chapter 20). The antibody blocks the binding of IgE to the high-affinity Fes receptor on basophils and mast cells, which suppresses IgE-mediated release of type I allergy mediators such as histamine and leukotrienes. Total serum IgE levels may remain elevated in patients for up to 1 year after administration of this antibody. 

Burrows B, Martinez FD, Halonen M, Barbee RA, et al. 1989. Association of asthma with serum IgE levels and skin-test reactivity to allergens. NEJM. 320 271-277. 

The pathogenesis of atopic dermatitis remains unclear, although there appears to be a relation to IgE, along with a genetic influence. Although investigators have focused on a dysfunctional immune system, there is no conclusive evidence to support the assumption that cell-mediated response occurs in atopic dermatitis. Elevated serum IgE levels may be found. 

Meyers DA, Postma DS, PanhuysenCIM,Xu J, Amelung PJ, Levitt RC, Bleekers ER Evidence for a locus regulating total serum IgE levels mapping to chromosome 5. Genomics 1994 23 464-70. 

From these data it might be expected that removal of CD8 T cells would enhance IgE production and favour TH2-type immune responses. However, this appears to depend on the stage at which depletion is carried out. Thus, if CD8 T cells are depleted in rats (using the mAb OX-8) in which an IgE response had been induced, then the usual decline in serum IgE levels is prevented (Holmes etal., 1994). This supports the view that CD8 T cells suppress IgE. However, if depletion of CD8 T cells is performed prior to immunization, then the IgE response is not enhanced. Moreover, the IgE response is... 

Rademecker, M., Bekhti, A., Poncelet., E. and Salmon., J. (1974). Serum IgE levels in protozoal and helminthic infections. Int. Arch. Allergy Appl. Immunol. 47, 285. 

Analogs of JL FPL-52757 (i.) and FPL-57787 (2.) have been reported to be orally effective In clinical trials while 4 was Ineffective In asthmatics. 3 A tetrazole analog AA-344 ( ) was 4 times as active as DSCG In the rat FCA and orally effective In 7 of asthmatic patients.Of,these 7 patients, 6 were RAST positive with high serum IgE levels. Although the tetrazolecarbonyl derivative 6 was very potent In the rat PGA test by the l.v. route (ED5o 037 mg/kg),... 

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