Serum enterolactone

In our study we used serum enterolactone as a marker of bioavailability of phloem polyphenols from the wood matrix. As a result of the four-week... 

Substantial individual differences were observed in the response to study breads and the ranges of enterolactone concentration changes in the groups were as follows -54.5-60.0 nmol/1 (placebo), -26.2-101.3 nmol/1 (LP), -19.6-81.8 nmol/1 (HP). This was something that could have been expected as in several studies dietary factors have explained only 10% of the variation in serum enterolactone (Vanharanta et al, 2002b Kilkkinen et al., 2001). This gives further support to the major role of intestinal bacteria in the synthesis of enterolactone. Decreased concentrations of enterolactone may occur due to an increased fiber intake, which may shorten the retention time in the colon and lead to incomplete metabolism of plant lignans. Constipation was earlier shown to be associated with an increased level of serum enterolactone (Kilkkinen et al., 2001). 

KILKKINEN A, STUMPF K, PIETINEN P, VALSTA L M, TAPANAINEN H, ADLERCREUTZ H (2001) Determinants of serum enterolactone concentration, American Journal of Clinical Nutrition 73, 1094-1100. 

VANHARANTA M, MURSU J, VOUTILAINEN S, RISSANEN T H, NURMI T, SALONEN R, ADLERCREUTZ C H, SALONEN J T (2002a) Rye bread fortified with phloem increases serum enterolactone level, European Journal of Clinical Nutrition, in press. 

VANHARANTA M, VOUTILAINEN S, NURMI T, KAIKKONEN J, ROBERTS L J, MORROW J D, ADLERCREUTZ H, SALONEN J T (2002b) Association between low serum enterolactone and increased plasma F2-isoprostanes, a measure of lipid peroxidation, Atherosclerosis, 160,465-9. 

Pietinen, P., Stumpf, K., Mannisto, S., Kataja, V., Uusitupa, M., and Adlercreutz, H., Serum enterolactone and risk of breast cancer a case-control study in eastern Finland, Cancer Epidemiol. Biomarkers Prev., 10, 339, 2001. 

Boccardo, F., Lunardi, G., Guglielmini, P., Parodi, M., Murialdo, R., Schettini, G., and Ruba-gotti. A., Serum enterolactone levels and the risk of breast cancer in women with palpable cysts, Eur. J. Cancer, 40, 84, 2004. 

Kilkkinen, A., Virtamo, J., Vartiainen, E., Sankila, R., Virtanen, M.J., Adlercreutz, H., and Pietinen, P., Serum enterolactone concentration is not associated with breast cancer risk in a nested case-control study, Int. J. Cancer, 108, 277, 2004. 

Serum enterolactone was measured in a cross-sectional study in Finnish adults. In men, serum enterolactone concentrations were positively associated with consumption of whole-grain products. Variability in serum enterolactone concentration was great, suggesting the role of gut microflora in the metabolism of hgnans may be important. Kilkkinen et al. also report that intake of lignans is associated with... 

Kilkkinen A., et al.. Intake of lignans is associated with serum enterolactone concentration in Finnish men and women. J. Nutr. 133, 1830, 2003. 

Guglielmini P, Rubagotti A, Boccardo E. Serum enterolactone levels and mortality outcome in women with early breast cancer a retrospective cohort study. Breast Cancer Res Treat. 2012 132 661-668. 

Stumpf K, Pietinen P, Puska P, Adlercreutz H. Changes in serum enterolactone, genistein, and daidzein in a dietary intervention study in Finland. Cancer Epidemiol Biomarkers Preu. 2000 9 1369-1372. 

Juntunen KS, Mazur WM, Liukkonen KH, et al. Consumption of wholemeal rye bread increases serum concentrations and urinary excretion of enterolactone compared with consumption of white wheat bread in healthy Finnish men and women. Br J Nutr. 2000 84 839-846. Vanharanta M, Mursu J, Nurmi T, et al. Phloem fortification in rye bread elevates serum enterolactone level. Eur J Clin Nutr. 2002 56 952-957. McIntosh GH, Noakes M, Royle PJ, Foster PR. Whole-grain rye and wheat foods and markers of bowel health in overweight middle-aged men. Am J Clin Nutr. 2003 77 967-974. 

Kristensen MB, Hels O, Tetens I. No changes in serum enterolactone levels after eight weeks intake of rye-bran products in healthy young men. Scandinavian Journal of Food Nutrition. 2005 49 62-67. 

Kilkkinen A, Stumpf K, Pietinen P, Valsta LM, Tapanainen H, Adlercreutz H. Determinants of serum enterolactone concentration. Am J Clin Nutr. 2001 73 1094-1100. 

Jacobs DR, Pereira MA, Stumpf K, Pins JJ, Adlercreutz H. Whole grain food intake elevates serum enterolactone. Br J Nutr. 2002 88 111-116. 

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