Serotonin transporter methamphetamine

Rawson RA, Gonzales R, Brethen P Treatment of methamphetamine use disorders an update. J Subst Abuse Treat 23 145—150, 2002a Rawson RA, Huber A, Brethen P, et al Status of methamphetamine users 2—5 years after outpatient treatment. J Addict Dis 21 107—119, 2002b Reneman L, Lavalaye J, Schmand B, et al Cortical serotonin transporter density and verbal memory in individuals who stopped using 3,4-methylenedioxymetham-phetamine (MDMA or ecstasy ) preliminary findings (comment). Arch Gen Psychiatry 58 901—906, 2001... 

Rudnick G, Wall SC (1992) The molecular mechanism of ecstasy [3,4-methylenedioxy-methamphetamine (MDMA)] serotonin transporters are targets for MDMA-induced serotonin release. Proc Natl Acad Sci USA 89 1817-1821. 

Methamphetamine (MAP) is a psychostimulant that induces enhanced arousal and euphoria acutely, and psychosis and addiction chronically. MAP enters the terminals/neuron via the monoamine transporters (dopamine transporter DAT, serotonin transporter SERT, or norepinephrine transporter NET), displaces... 

Amphetamine and related substances show symphaticomimetic and CNS stimulant activity. Amphetamines are indirect monoamine agonists and interact with the membrane transporters involved in neurotransmitter reuptake and vesicular storage systems. Therefore, they stimulate the release of norepinephrine, dopamine, and serotonin from presynaptic terminals in the CNS and at the peripheral level (De La Torre et al., 2004). Methamphetamine and the methylenedioxy derivatives (MDA, MDMA, MDEA, MBDB) can inhibit the activity of enzymes of dopamine or serotonin biosynthesis (De La Torre et al., 2004). 

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