Serotonin 5-HT1B receptor

Leone AM, Errico M, Lin SL, Cowen DS. Activation of extracellular signal-regulated kinase (ERK) and Akt by human serotonin 5-HT1B receptors in transfected BE(2)-C neuroblastoma cells is inhibited by RGS4. J Neurochem 2000 75 934-938. 

Pullarkat SR, Mysels DJ, Tan M, Cowen DS. Coupling of serotonin 5-HT1B receptors to activation of mitogen-activated protein kinase (ERK-2) and p70 S6 kinase signaling systems. J Neurochem 1998 71 1059-1067. 

Koe BK, Lebel LA, Fox CB, Macor JE. Characterization of [3H]CP-96,501 as a selective radioligand for the serotonin 5-HT1B receptor binding studies in rat brain membranes. J Neurochem 1992 58 1268-1276. 

Levitan, R. D., A. S. Kaplan, M. Masellis, V. S. Basile, M. L. Walker, N. Lipson, et al. (2001). Polymorphism of the serotonin 5-HT1B receptor gene (HTR1B) associated with minimum lifetime body mass index in women with bulimia nervosa. Biol Psychiatry 50(8) 640-3. 

Initial attention in the serotonin field was focused on the first three receptor populations to be identified 5-HT1A, 5-HT1B, and 5-HT2 receptors. However, once the presence of 5-HT1B receptors in the human brain was questioned, interest in this population temporarily subsided. With the discovery of a new population of 5-HTj receptors, 5-HT1D receptors, came the realization of a structural and functional similarity between 5-HT1B and 5-HT1D receptors. On the basis of... 

Mendez J, Kadia TM, Somayazula RK, El-Badawi KI, Cowen DS. Differential coupling of serotonin 5-HT1A and 5-HT1B receptors to activation of ERK2 and inhibition of adenylyl cyclase in transfected CHO cells. J Neurochem 1999 73 162-168. 

Seuwen K, Magnaldo I, Pouyssegur J. Serotonin stimulates DNA synthesis in fibroblasts acting through 5-HT1B receptors coupled to a G, protein. Nature 1988 335 254-256. 

Hamblin MW, Metcalf MA, McGuffin RW, Karpells S. Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor a homologue of the rat 5-HT1B receptor with 5-HTlD-like pharmacological specificity. Biochem Biophys Res Commun 1992 184 752-759. 

Ase AR, Reader TA, Hen R, Riad M, Descarries L. Altered serotonin and dopamine metabolism in the CNS of serotonin 5-HT1A or 5-HT1B receptor knockout mice. J Neurochem 2000 75 2415-2426. 

Adell A, Celada P, Artigas F. The role of 5-HT1B receptors in the regulation of serotonin cell firing and release in the rat brain. J Neurochem 2001 79 172-182. 

Mlinar B, Corradetti R. Endogenous 5-HT, released by MDMA through serotonin transporter- and secretory vesicle-dependent mechanisms, reduces hippocampal excitatory synaptic transmission by preferential activation of 5-HT1B receptors located on CA1 pyramidal neurons. Eur J Neurosci 2003 18 1559-1571. 

De Groote L, Olivier B, Westenberg HG. Role of 5-HT1B receptors in the regulation of extracellular serotonin and dopamine in the dorsal striatum of mice. Eur J Pharmacol 2003 476 71-77. 

Gardier AM, David DJ, Jego G, et al. Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice. J Neurochem 2003 86 13-24. 

Fabre V, Beaufour C, Evrard A, Rioux A, Hanoun N, et al. 2000. Altered expression and functions of serotonin 5-HT 1A and 5-HT1B receptors in knock-out mice lacking the 5-HT transporter. Eur. J. Neurosci. 12 2299-310... 

Riad, M., Garcia, S., Watkins, K. C. et al. Somatodendritic localization of 5-HT1A and preterminal axonal localization of 5-HT1B serotonin receptors in adult rat brain. /. Comp. Neurol. 417 181-194, 2000. 

Xie, Z., Lee, S. P., O Dowd, B. F., and George, S. R. (1999) Serotonin 5-HT1B and 5-HT1D receptors form homodimers when expressed alone and heterodimers when coexpressed. FEBS Lett. 456, 63-67. 

Hamblin MW, McGuffin RW, Metcalf MA, Dorsa DM, Merchant KM. Distinct 5-HT1B and 5-HT1D serotonin receptors in rat structural and pharmacological comparison of the two cloned receptors. Mol Cell Neurosci 1992 3 578-587. 

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