Central serotonergic system

Chaouloff, F (1993) Physiopharmacological interactions between stress hormones and central serotonergic systems. Brain Res. 18 1-32. 

Another instructive example of the relevance of ambient stimuli to the nature of the effect of serotonergic manipulations on locomotor activity is provided by Brody s (27) study of PCPA. He monitored the locomotion of vehicle- and PCPA-treated rats in an open field to which the animals had been previously familiarized. Animals were tested either with or without additional stimulation in the form of flashing lights and 90 dB(A) noise bursts. Without stimulation, PCPA-treated rats were less active than controls with stimulation, PCPA-treated rats were more active. The results of these and other such studies indicate that the central serotonergic systems may not directly modulate the level of locomotor activity per se, but they may profoundly influence locomotor activity by virtue of their effects on the sensory responsivity of the animal to a wide variety of environmental stimuli. 

Xiang XN, Wang HL, Wu WR, Cao DV, Wang HS, Zhao Y (2006) Ethological analysis of scopolamine pretreatment in morphine dependent rats. Physiol Behav 88 183-90 Yasuda K, Suemaru K, Araki H, Gomita Y (2002) Effect of nicotine cessation on the central serotonergic systems in mice involvement of 5-HT(2) receptors. Naunyn Schmiedbergs Arch Pharmacol 366 276-281... 

Pucilowski, O. and Kostowski, W. (1983) Aggressive behavior and the central serotonergic system. Brain Res 9 33 8. 

Vetulani J, Lebrecht V, Pile A. Enhancement of responsiveness of the central serotonergic system and serotonin-2 receptor density in rat frontal cortex by electroconvulsive treatment. EurJ Pharmacol 1981 76 81. 

Haysett RL, Tizabi Y (2005) Effects of donepezil, nicotine and haloperidol on the central serotonergic system in mice implications for Tourette s syndrome. Pharmacol Biochem Behav... 

Kulikov, A., Aguerre, S., Berton, O., Ramos, A., Mormede, P., and Chaouloff, E., Central serotonergic systems in the spontaneously hypertensive and Lewis rat strains that differ in the elevated plus-maze test of anxiety, /. Pharmacol. Exp. Then, 281, 775, 1997. 

Coccaro, E. F., Impulsive aggression and central serotonergic system function in humans An example of a dimensional brain-behavior relationship, Int. Clin. Psychopharmacol., 7, 3, 1992. 

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