Sequential gene expression

The subsequent induction of enzymes which belong to one metabolic pathway by the products of preceding enzymes (sequential gene expression), is a characteristic of catabolic pathways in bacteria. Although sequential formation of secondary products and secondary metabolic enzymes in many plants and microorganisms has been observed the direct influence of secondary products on the expression of enzymes catalyzing their further transformation has been demonstrated in very few organisms. 

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Dekel B, Bocher WO, Marcus H, Yussim A, Reisner Y. Acute cellular rejection of human renal tissue by adoptive transfer of allogeneic human peripheral blood mononuclear cells into chimeric rats sequential gene expression of cytokines, chemokines and cytolytic elFector molecules, and their regulation by CTLA-4-Ig. Int. Immunol. 1999 11 1673-1683. 

Scheres, B., van Engelen, F., van der Knaap, E., van de Wiel, C., van Kammen, A. Bisseling, T. (1990b). Sequential induction of nodulin gene expression in the developing pea nodule. The Plant Cell 2,687-700. 

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