Sensitizer, 4-187 splash goggles

Because of its high toxicity, carcinogenicity, and ability to cause sensitization, toluene diisocyanate should be handled using the "basic prudent practices" of Chapter 5.C, supplemented by the additional precautions for work with compounds of high toxicity (Chapter 5.D). In particular, work with TDI should be conducted in a fume hood to prevent exposure by inhalation, and splash goggles and impermeable gloves should be worn at all times to prevent eye and skin contact. 

Toxicology LDLo (oral, mouse) 3 g/kg, (subcut, mouse) 900 mg/kg, (IV, mouse) 1000 mg/kg poison by IV route mod. toxic by ing, subcut, routes highly toxic by in],—destroys red blood cells severe irritant possible sensitizer sternutator experimental reproductive effector target organs blood, Gl system, nerves, liver Environmental Toxic to fish Precaution Wear splash goggles and lab coat... 

In addition to splashes and shrapnel, eyes are sensitive to ultraviolet (UV) and visible radiation. While normal levels of visible light are not harmful, exposure to either visible or UV lasers presents a significant hazard. Lasers are discussed separately in Section 7.3.3. Ultraviolet radiation hazards are discussed in Section 5.3.7 and special safety glasses and goggles are available to protect your eyes against this radiation. 

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