Semipermeable polymeric membrane devices

A straightforward way to collect solutes from the interstitial fluid (ISF) space would be to have a semipermeable, hollow fiber, membrane-based device as originally described by Bito et al.1 Two semipermeable membrane-based devices that have been used to collect different types of analytes from various mammalian tissues include microdialysis sampling probes (catheters) and ultrafiltration probes. The heart of each of these devices is the semipermeable polymeric membrane shown in Figure 6.1. The membranes allow for collection of analytes from the ISF that are below the membrane molecular weight cutoff (MWCO). Each of these devices provides a sample that has a significantly reduced amount of protein when compared to either blood or tissue... 

Figure 8.34 Examples of drug-delivery systems employing polymeric membranes, (o) Ocusert system for the eye with two rote-controlling membranes, (b) Tronsiderm system for transdermal medication with one rote-controlling layer, (c) The Progestasert device for intrauterine insertion in which the body of the device serves as the rote-controlling barrier, (d) The oral Oros device in which the membrane is o semipermeable membrane which forbids drug transport, allowing water ingress only.

Supported liquid membranes (SLMs) or semipermeable membrane devices (SPMDs) SLMs are passive in situ partitioning systems monitoring dissolved organic contaminants (in air/water/sediments). A porous polymeric... 

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