Seltzer studies

Seltzer SE, Shulkin PM, Adams DF (1984) Usefulness of liposomes carrying losefamate for CT opacification of liver and spleen. Am J Roentgenol 143 575 Payne Nl, Whitehouse GH (1987) Delineation of the spleen by a combination of proliposomes with water-soluble contrast media an experimental study using computed tomography. Brit J Radiol 60 535... 

Seltzer /. Am. Chem. Soc. 1963, 85, 1360, 1965,87, 1534. For a review of isotope effect studies of Diels-Alder and other pcricyclic reactions, sec Gajewski Isot. Org. Chem. 1987, 7, 115-176. 

Crawford and Tagaki have examined gas-phase decompositions of several azo compounds with R = CH3, /-butyl, or allyl they found that most of these compounds, both symmetric and unsymmetric, decompose by the noncon-certed path (Equation 9.29).87 Seltzer found by studying secondary deuterium isotope effects that in unsymmetrical azo compounds in which one R group is a much better radical than the other, the bond breaking is stepwise.68 In a compound such as 20, substitution of the hydrogen on the a-phenylethyl side gives... 

There is some evidence that donepezil may have benefits in patients with early stage Alzheimer s disease whose symptoms no longer qualifies them for mild cognitive impairment [37]. A study by Seltzer and colleagues enrolled 153 patients with basehne MMSE scores of 21-26 with mild impairment of activities of daily hving. In this double-blind, randomized, placebo-controlled study, subjects were followed over 24 weeks and were assessed with the ADAS-cog and the MMSE as primary measures. The trial results showed a statistical significance in both measures, although the improvements were modest with a 2.3 point improvement in the ADAS-cog and a 1.8 point improvement in the MMSE at the end of 24 weeks compared with placebo [37]. 

Shalat SL, Seltzer B, Baker EL Jr Occupational risk factors and Alzheimer s disease a case-control study. J Occup Med 30 934-936,1988 Sherman JE Inherently dangerous industry approach, in Chemical Exposure and Disease Diagnostic and Investigative Techniques. Edited by Sherman JD. New York, Van Nostrand Reinhold, 1988, pp 72-96... 

Warren RW (1970) EPR of Mn in calcium fluorophosphates. 1. The Ca (11) site. Phys Rev B 2 4383-4388 Waychunas G (1989) Luminescence, X-ray emission and new spectroscopies. Rev Mineral 18 638-698 Wright AO, Seltzer MD, Graber JB, Zandi B, Merkle LD, Chai BHT (1996) Spectroscopic investigation of Pr in fluorapatite crystals. JPhys Chem Solids 57 1337-1350 Xiong J (1995) Cathodoluminescence studies of feldspars and apatites from the Coldwell alkaline complex. MSc thesis, Lakehead Univ, Thunder Bay, Ontario... 

Independent, blinded, clinical endpoint committees are regularly conunissioned to adjudicate potential cardiovascular endpoints in trials examining the efficacy of cardiovascular drugs as well as cardiovascular endpoints in cardiovascular safety outcome studies (see Seltzer et al. 2015). 

Seltzer, C. C., "Some Re-evaluations of the Build and Blood Pressure Study, 1959, as Related to Ponderal Index, Somatotype and Mortality," New England Journal of Medicine, Vol. 274,19, p. 254. 

The most ambitious investigation of an isotope effect of this kind is Seltzer s (107) study of the maleic-fumaric acid isomerization in water, catalyzed by thiocyanate ion. Here, AAF" " varies from —100 cal. at 15°C. to —85 cal. at 80°C., and is thus just in the 10-15% range observed by Denny and Tunkel (102) for their reactions with stilbene. The temperature dependence yields an experimental activation energy difference of —125 cal. 

Quantitative arguments have been used with varying success in dealing with secondary isotope effects on reactions of uncertain mechanism. Seltzer (113) has studied the radical cleavage ... 

Less clear-cut are the conclusions from Seltzer s (129) study of the reiro-Diels-Alder reaction, illustrated in Figure 10, in an attempt to ascertain whether bond rupture is stepwise or simultaneous. It might be noted that the reactant is the exo adduct, so that the present result cannot be directly related to the effect in the forward reaction measured by Van SicUe (105) (Sec. VA, 1). When the hydrogen atoms at a and b are deuterium, the effect is kn/kn = 1.15. When only the atom at c is deuterium, ftn/fen is 1.07. Most simply, this would be taken to mean a 7-8% contribution to h/ d from each of three CH bonds undergoing simultaneous spatial reorientation. Seltzer, however, regards such an effect as only about half the normal magnitude. 

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