Self-nonself

Percus J K, Percus O E and Perelson A S 1993 Predicting the size of the T-cell receptor and antibody combining region from consideration of efficient self-nonself discrimination Proc. Natl Acad. Sci. USA 90 1691-5... 

The common microbial patterns render recognition by organisms and their self/ nonself recognition is based on innate mechanisms. The common microbial patterns include lipopolysaccharides (LPS), mannose, fucose, technoic acid and /V-formyl peptides. These common microbial patterns are called pattern recognition molecules (PRMs) or pattern recognition receptors (PRRs). 

Tolerance to self-antigens is learned by the immune system, not inherited as self-nonself discrimination (Bretscher and Cohn, 1970). Auto-antibodies against a large number of self-antigens may occur in sera of normal individuals. Their levels can be raised by stimulation with polyclonal B-cell mitogens. 

Klein, J. (1982) Immunology. The Science of Self-nonself Discrimination. John Wiley and Sons, Chichester, New York. 

Self-nonself Danger Self-nonself Danger... 

Baker MP, Reynolds HM, Lumicisi B, Bryson CJ. Immunogenicity of protein therapeutics the key causes, consequences and challenges. Self/Nonself—Immune Recognition and Signaling. 2010 l(4) 314-22. 

The danger model introduced by Polly Matzinger altered the previously favored self-nonself hypothesis of immune response, by postulating that self biomolecules are potential DAMPs that can be recognized by germline encoded PRRs,... 

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