Danger model

Matzinger P. The danger model a renewed sense of self. Science 2002 296 301-305. 

Use of the Danger Model to Produce New Animal Models of IDRs. 504... 

Although it must be considered just a theory at present, the danger model has significantly changed our perspective on what is involved in the induction of an immune response, and it has obvious implications for idiosyncratic drug reactions, most of which are likely immune-mediated. 

Matzinger, P. 2001. The danger model in its historical context. Scandjournal immunology 54 4-9. 

The danger model introduced by Polly Matzinger altered the previously favored self-nonself hypothesis of immune response, by postulating that self biomolecules are potential DAMPs that can be recognized by germline encoded PRRs,... 

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