Self-assembly functional macrocycle synthesis

Self-Assembly in the Synthesis of Functional Macrocycle Assemblies... 

Adamantane can be used to construct peptidic scaffolding and synthesis of artificial proteins. It has been introduced into different types of synthetic peptidic macrocycles, which are useful tools in peptide chemistry and stereochemistry studies and have many other applications as well. Introduction of amino acid-functionalized adamantane to the DNA nanostmctures might lead to construction of DNA-adamantane-amino acid nanostmctures with desirable stiffness and integrity. Diamondoids can be employed to constmct molecular rods, cages, and containers and also for utilization in different methods of self-assembly. In fact, through the development of self-assembly approaches and utilization of diamondoids in these processes, it would be possible to design and constmct novel nanostmctures for effective and specific carriers for each dmg. 

Nanotubes represent spatially defined nano-containers with chemically defined inside and outside properties and up to two openings for mass exchange with the surrounding environment. Such functional geometric objects have attracted the attention of synthetic chemists for many years and many different synthetic approaches have been exploited to create such structures. Most approaches can be roughly divided into covalent and non-covalent synthetic strategies. The latter can be formed from, for example, stacked macrocycles or via self-assembly of low molecular weight amphiphiles, " peptides,proteins,or deoxyribonucleic acids (DNA). Several excellent articles have been published that review the field of nanotube synthesis up to the year 2005. " ... 

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