Selective toxicity monoclonal antibodies

This approach appears somewhat irrational and without much scientific merit, since many of these new molecules are minimally toxic or nontoxic by this sort of acute evaluation. As in the case of interferons or monoclonal antibodies, the toxic effects observed in humans might not be predicted from safety assessments in rodents. An appropriate test species should be selected. Is the rat or mouse the appropriate species to evaluate a species-specific rDNA protein such as human growth hormone or interferons, or would nonhuman primates be more suitable Does the nonhuman primate really offer any advantages There is some consensus that the nonhuman primate may be a more appropriate species for testing some rDNA human proteins. 

Another approach to selectively inducing tumour cell kilhng is by the use of bispecific monoclonal antibodies (BsMAb).They combine the specificity of two separate antibodies within one molecule and cross-hnk an effector killer cell or a toxic molecule with the target cell to be destroyed [75]. There are three major approaches for creating BsMAbs.They can be obtained by chemical cross-linking of two MAbs, by fusing two hybridomas [76], or by genetic... 

Monoclonal antibodies directed against specific antigens such as CD3, CD4, CD25, CD40, IL-2 receptor, and TNF-a (discussed below) much more selectively influence T-cell subset function. The high specificity of these antibodies improves selectivity and reduces toxicity of the therapy and alters the disease course in several different autoimmune disorders. 

Tissue Cross-Reactivity Studies for Monoclonal Antibodies Predictive Value and Use for Selection of Relevant Animal Species for Toxicity Testing... 

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