Selective serotonin reuptake inhibitors pharmacokinetic

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Hiemke C. and S. Harther (2000). Pharmacokinetics of selective serotonin reuptake inhibitors. Pharmacology and Therapeutics 85 11-28. 

PEDIATRIC PHARMACOKINETIC SELECTIVE SEROTONIN REUPTAKE INHIBITOR STUDIES... 

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Psychiatric patients often take multiple psychotropic medications and have medical illnesses that require additional pharmacother-apeutic treatments. Psychiatric practitioners must recognize that administration of multiple medications can alter pharmacokinetic profiles of compounds that are biotransformed by the CYP enzymes. For example, the addition of the popular selective serotonin reuptake inhibitor (SSRI) fluoxetine to a treatment regimen for depression that includes the TCA desipramine has been reported to produce toxic levels of the TCA because of competi-... 

Preskom SH. CUnically relevant pUarmacology of selective serotonin reuptake inhibitors An overview with emphasis on pharmacokinetics and effects on oxidative drug metaboUsm. Qin Pharmacokinet 1997 32(Suppl 1) 1-21. 

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A. Classification and Pharmacokinetics The major classes of antidepressant drugs are shown in Figure 30-1 tricyclic antidepressants, heterocyclic antidepressants, selective serotonin reuptake inhibitors, and monoamine oxidase inhibitors. 

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