Selective List Scheme

To indicate that the criteria within this part of the Drug Tariff have been met, the prescriber must endorse the prescription SLS (Selective List Scheme) (or S. 11 in Northern Ireland). Pharmacists should not dispense any item listed in these respective Parts of the Drug Tariff unless it has been endorsed SLS (or S. 11 ) by the prescriber. It is not the role of the pharmacist to verify that the patient is indeed being treated for a listed condition this is the responsibility of the prescriber. 

Item(s) allowable on the NHS Yes, see Drug Tariff. The medication ordered indicates that the patient is diabetic therefore tadalafil may be prescribed under the selected list scheme. Return the prescription to the prescriber to ask him to add SLS to the body of the prescription next to the order for Cialis so that it will be passed for payment by the PPD. 

First statement Amantadine is not prescribable under the NHS except as indicated in National Institute for Clinical Excellence guidance, when prescriptions must be endorsed Selected List Scheme (SLS). 

A select list of species containing sulfur plus an additional heteroatom is given in Table III. These groups of compounds have been observed in coal derived products from various sources. To be able to make reasonable comparisons only data from bituminous coals are used. Possible structures for the formulae given in Table III are shown in Scheme I. It should be emphasized that further information is necessary to positively assign structures. The viability of these structural assignments will be discussed in the next three sections. 

When ligands have vacant it or d orbitals, there is the possibility of tt back-bonding, and the ligands are tt acceptors. This addition to the bonding scheme increases A. Ligands that do this very effectively include CN , CO, and many others. A selected list of these ligands in order is... 

Thus, according to the Q-e scheme, by assigning values to Q and e, it should be possible to evaluate rj and rj for any monomer pair. A selected list of Q and e values is shown in Table 8.6. Negative values of e indicate electron-rich monomers, while positive e values indicate electron-poor monomers. 

Scheme 5.2 Selective list of linked half-titanocenes employed for ethylene/styrene copolymerization [16,17].

A further detail of this study included sensitivity analysis for the area of heat exchangers, discount rate, and fuel cost. The results are listed in Table 3-8. Option 2, the turboexpander scheme, was selected in terms of energy and maintenance savings, as well as enhanced reliability, availability, and safety. 

Enantioselectivities were found to change sharply depending upon the reaction conditions including catalyst structure, reaction temperature, solvent, and additives. Some representative examples of such selectivity dependence are listed in Scheme 7.42. The thiol adduct was formed with 79% ee (81% yield) when the reaction was catalyzed by the J ,J -DBFOX/Ph aqua nickel(II) complex at room temperature in dichloromethane. Reactions using either the anhydrous complex or the aqua complex with MS 4 A gave a racemic adduct, however, indicating that the aqua complex should be more favored than the anhydrous complex in thiol conjugate additions. Slow addition of thiophenol to the dichloromethane solution of 3-crotonoyl-2-oxazolidinone was ineffective for enantioselectivity. Enantioselectivity was dramatically lowered and reversed to -17% ee in the reaction at -78 °C. A similar tendency was observed in the reactions in diethyl ether and THF. For example, a satisfactory enantioselectivity (80% ee) was observed in the reaction in THF at room temperature, while the selectivity almost disappeared (7% ee) at 0°C. 

Heterocyclic compounds are of great interest to the pharmaceutical industry, as they make up most of the known pharmacophores. As a result, a number of libraries of various heterocycles have been prepared using polymer-supported reagents. While an exhaustive list of all the heterocychc cores that have been prepared using PSRs is beyond the scope of this chapter, some selected examples are depicted in Scheme 3. 

The remaining carbon compounds fall into the category of organic molecules. The number of identified species is large - at least several hundred - so we cannot produce an exhaustive list here. Instead we will list molecular forms following conventional schemes for organic chemistry with a few selected samples. 

Jorgensen s group reported the aza Diels-Alder reactions in the presence of several chiral catalysts.52 They found that chiral bis(oxazoline) ligands 81, 83, 103, 104, and 105, which were effective in asymmetric oxo hetero Diels-Alder reactions, induced the aza Diels-Alder reaction of a-imino ester with Danishefsky s diene with only poor to moderate enantioselectivity. Selected results are listed in Scheme 5-40. 

Tab. 6.1 Selected hydrogenation experiments with polymeric amphiphiles (experimental data are listed in Scheme 6.2, R, =COOMe, R2=Me).

The hydrocarboxylation of styrene (Scheme 5.12) and styrene derivatives results in the formation of arylpropionic acids. Members of the a-arylpropionic acid family are potent non-steroidal anti-inflammatory dmgs (Ibuprofen, Naproxen etc.), therefore a direct and simple route to such compounds is of considerable industrial interest. In fact, there are several patents describing the production of a-arylpropionic acids by hydroxycarbonylation [51,53] (several more listed in [52]). The carbonylation of styrene itself serves as a useful test reaction in order to learn the properties of new catalytic systems, such as activity, selectivity to acids, regioselectivity (1/b ratio) and enantioselectivity (e.e.) in the branched product. In aqueous or in aqueous/organic biphasic systems complexes of palladium were studied exclusively, and the results are summarized in Table 5.2. 

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