Selective estrogen receptor modulator SERM

Selective estrogen receptor modulators (SERMs) are synthetic compounds with partially agonistic and partially antagonistic estrogenic properties. In bone, SERMs inhibit bone resorption via the mechanisms known for estrogens. Major SERMs are tamoxifen, a triphenylethylene compound, and raloxifene. In postmenopausal women, the latter has been shown to prevent bone loss and to reduce fracture risk by 40%. 

SETCHELL K D (2001) Soy isoflavones-benefits and risks from nature s selective estrogen receptor modulators (SERMs). J Am Coll Nutr. 20 (5 Suppl) 354S-362S. 

Clinical Pharmacology of Selective Estrogen Receptor Modulators (SERMs)... 

Lonard DM, Smith CL (2002) Molecular perspectives on selective estrogen receptor modulators (SERMs) progress in understanding their tissue-specific agonist and antagonist actions. Steroids 67 15-24... 

Tou L, Quibria N, Alexander JM (2001) Regulation ofhuman cbfal gene transcription in osteoblasts by selective estrogen receptor modulators (SERMs). Mol Cell Endocrinol 183 71-79... 

The present chapter describes current knowledge regarding the effects of selective estrogen receptor modulators (SERMs) on these two gynecological conditions. 

Muchmore DB (2000) Raloxifene a selective estrogen receptor modulator (SERM) with multiple target system effects. Oncologist 5 388-392... 

Aromatase inhibitors (including anastrozole, letrozole, aminoglutethimide, exemestane, formestane, testolactone), selective estrogen receptor modulators—SERMs (including raloxifene, tamoxifen, toremifene), clomiphene, cyclofenil, fulvestrant Diuretics, amiloride, bumetanide, canrenone, chlorthalidone, etacrynic acid, furosemide, indapamide, metolazone, spironolactone, thiazides, triamterene... 

Diel, P., Olff, S., Schmidt, S. and Michna, FI. (2001). Molecular identification of potential selective estrogen receptor modulator (SERM) like properties of phytoestrogens in the human breast cancer cell line MCF-7, Planta Med., Aug, 67, 6, 510-514. 

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